SCEL - sciellin Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8796

About SCEL

Cytogenetic location: 13q22.3 Genomic coordinates (GRCh38): 13:77,535,706-77,645,263 (from NCBI)

This gene has 5 transcripts (splice variants), 146 orthologues and 1 paralogue. Biased expression in esophagus (RPKM 207.5), skin (RPKM 141.4) and 1 other tissue.

Summary

The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

SCEL Products (3)

mRNA Protein Name
NM_001160706.2 NP_001154178.1 sciellin isoform 3
NM_003843.4 NP_003834.3 sciellin isoform 2
NM_144777.3 NP_659001.2 sciellin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14632196 GOA
Biological Process GO Annotation Evidence References Source
involved in keratinocyte differentiation IDA
IDA: Inferred from direct assay
14632196 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
27013588 GOA
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19211270 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9813070 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19211270 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sciellin

SCEL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCEL O95171 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra
SCEL O95171 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra
SCEL O95171 NMI Homo sapiens Q13287
Validated Y2H
25416956
Intra
SCEL O95171 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
Intra
SCEL O95171 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
SCEL O95171 GOLGA2 Homo sapiens Q08379
Y2H
21516116
Intra
SCEL O95171 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
SCEL O95171 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
SCEL O95171 FXR2 Homo sapiens P51116
Y2H Array
31515488
Intra
SCEL O95171 FXR2 Homo sapiens P51116
Validated Y2H
25416956
Intra
SCEL O95171 FXR2 Homo sapiens P51116
Y2H Array
25416956
Intra
SCEL O95171 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
SCEL O95171 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
SCEL O95171 TSGA10 Homo sapiens Q9BZW7
Y2H Prey Pooling
25416956
Intra
SCEL O95171 TSGA10 Homo sapiens Q9BZW7
Validated Y2H
25416956
Intra
SCEL O95171 TSGA10 Homo sapiens Q9BZW7
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12498 SCEL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22318 Scel Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28840 Scel Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SCEL VGNC VGNC:45902
Bos taurus SCEL VGNC VGNC:34329
Mus musculus SCEL MGD MGI:1891228
Rattus norvegicus SCEL RGD RGD:1305102
Macaca mulatta SCEL VGNC VGNC:76976
Felis catus SCEL VGNC VGNC:64906
Others SCEL NCBI