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製品番号: HY-100496

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Nucleocidin

Name: Nucleocidin
Brand: MedChemExpress
SKU: HY-100496
Availability: PreOrder

(別名: 4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007)

Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

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CAS 番号: 24751-69-7
分子式: C₁₀H₁₃FN₆O₆S
分子量:364.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Nucleocidin 構造式

CAS 番号: 24751-69-7

容量

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

IC₅₀ & Target

Antibacterial^[1].

体外実験

Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10^-3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10^-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 24751-69-7
分子量 364.31
分子式 C₁₀H₁₃FN₆O₆S
SMILES

O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@@]3(F)COS(=O)(N)=O
別名

4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces calvus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Florini JR, et al. Inhibition of protein synthesis in vitro and in vivo by nucleocidin, an antitrypanosomal antibiotic. J Biol Chem. 1966 Mar 10;241(5):1091-8. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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