ピリドキシン
Based on 7 publication(s) in Google Scholar
Pyridoxine (Pyridoxol) is one of the components of vitamin B6. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.98%
- CAS 番号: 65-23-6
- 分子式: C8H11NO3
- 分子量:169.18
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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MedChemExpress（MCE）の使用を引用している文献 Pyridoxine
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
- Microbiome. 2019 Mar 20;7(1):43. [Abstract]
- Cancer Lett. 2020 Nov 1;492:96-105. [Abstract]
- Dev Cell. 2025 Nov 27:S1534-5807(25)00691-4. [Abstract]
- Molecules. 2023 Apr 11;28(8):3375. [Abstract]
- Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
More
生物活性
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Microbial Metabolite |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
>1000 μM
Compound: Pyridoxine
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Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
|
[PMID: 21965623] |
| Sf21 | IC50 |
>1000 μM
Compound: Pyridoxine
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Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
|
[PMID: 21965623] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 65-23-6
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性状 Solid
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分子量 169.18
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分子式 C8H11NO3
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Color White to off-white
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SMILES
OCC1=C(CO)C(O)=C(C)N=C1
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別名
Pyridoxine; Pyridoxol
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (7)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Nat Commun
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. [Abstract]2020 Feb 18;11(1):941. PMID: 32071304
Pyridoxine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
Pyridoxine (1-80 μM; 12 h) had a greater effect on increasing GSH synthesis with lower cytotoxicity than vindoline in primary astrocytes.
Pyridoxine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
Pyridoxine (5 μM; 12 h) resulted in PKM2 dimerization in astrocytes.
Pyridoxine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
Pyridoxine (5 μM; 12 h) increased PKM2 binding to Nrf2 in astrocytes.
Pyridoxine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
Pyridoxine (5 μM; 12 h) enhanced Nrf2 binding to the promoters of Gclc/Gclm in astrocytes.
Pyridoxine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
Pyridoxine (5 μM; 12 h) promoted the mRNA expression of Gclc and Gclm in astrocytes.
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Microbiome
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]2019 Mar 20;7(1):43. PMID: 30890187 -
Cancer Lett
Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia. [Abstract]2020 Nov 1;492:96-105. PMID: 32860849 -
Dev Cell
2025 Nov 27:S1534-5807(25)00691-4. PMID: 41314217 -
Molecules
Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]2023 Apr 11;28(8):3375. PMID: 37110608 -
溶剤 & 溶解度
DMSO : 100 mg/mL (591.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (12.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (12.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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-
-
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.9109 mL | 29.5543 mL | 59.1086 mL | 147.7716 mL |
| 5 mM | 1.1822 mL | 5.9109 mL | 11.8217 mL | 29.5543 mL | |
| 10 mM | 0.5911 mL | 2.9554 mL | 5.9109 mL | 14.7772 mL | |
| 15 mM | 0.3941 mL | 1.9703 mL | 3.9406 mL | 9.8514 mL | |
| 20 mM | 0.2955 mL | 1.4777 mL | 2.9554 mL | 7.3886 mL | |
| 25 mM | 0.2364 mL | 1.1822 mL | 2.3643 mL | 5.9109 mL | |
| 30 mM | 0.1970 mL | 0.9851 mL | 1.9703 mL | 4.9257 mL | |
| 40 mM | 0.1478 mL | 0.7389 mL | 1.4777 mL | 3.6943 mL | |
| 50 mM | 0.1182 mL | 0.5911 mL | 1.1822 mL | 2.9554 mL | |
| 60 mM | 0.0985 mL | 0.4926 mL | 0.9851 mL | 2.4629 mL | |
| 80 mM | 0.0739 mL | 0.3694 mL | 0.7389 mL | 1.8471 mL | |
| 100 mM | 0.0591 mL | 0.2955 mL | 0.5911 mL | 1.4777 mL |
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