ロスバスタチンカルシウム
Based on 29 publication(s) in Google Scholar
Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.62%
- CAS 番号: 147098-20-2
- 分子式: C22H27Ca0.5FN3O6S
- 分子量:500.57
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-17502
SimvastatinHMGCR Inhibitor -
HY-B0589
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HY-N0504
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HY-14664
FluvastatinHMG-CoA Reductase Inhibitor -
HY-B0144
Pitavastatin CalciumHMG-CoA Reductase Inhibitor -
HY-17379
Atorvastatin hemicalcium saltHMGCR Inhibitor -
HY-B0144A
PitavastatinHMG-CoA Reductase Inhibitor -
HY-14664A
Fluvastatin sodiumHMG-CoA Reductase Inhibitor -
HY-17408
MevastatinHMG-CoA Reductase Inhibitor -
HY-10219
RapamycinmTOR Inhibitor -
HY-14648
DexamethasoneGR Agonist
MedChemExpress（MCE）の使用を引用している文献 Rosuvastatin Calcium
More- Cell Metab. 2025 Sep 2;37(9):1907-1925.e14. [Abstract]
- Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]
- MedComm (2020). 2024 Aug 31;5(9):e681. [Abstract]
- Biosens Bioelectron. 2025 Nov 15:288:117807. [Abstract]
- Phytomedicine. 2025 Sep:145:157014. [Abstract]
- Phytomedicine. 2024 Jul:129:155621. [Abstract]
- Cell Death Discov. 2024 May 29;10(1):263. [Abstract]
- Acta Pharmacol Sin. 2023 Jul;44(7):1416-1428. [Abstract]
- Free Radic Biol Med. 2026 Jun 24:254:360-369. [Abstract]
- J Med Chem. 2026 Aug 13;69(15):18431-18449.
- Front Bioeng Biotechnol. 2022 Mar 17;10:826093. [Abstract]
- Eur J Pharmacol. 2023 Sep 15:955:175911. [Abstract]
- Front Cell Dev Biol. 2022 Mar 3;10:806081. [Abstract]
- Front Cell Dev Biol. 2021 May 6;9:651579. [Abstract]
- ACS Omega. 2025 Oct 29;10(44):52562-52575. [Abstract]
- Cell Signal. 2025 Jul:131:111753. [Abstract]
- J Inflamm Res. 2021 Apr 16:14:1537-1549. [Abstract]
- FASEB J. 2026 May 15;40(9):e71873. [Abstract]
- Pharm Res. 2025 Oct 27. [Abstract]
- Front Oncol. 2021 May 10:11:595285. [Abstract]
- PLoS One. 2026 Feb 20;21(2):e0339967. [Abstract]
- Exp Ther Med. 2021 Oct;22(4):1189. [Abstract]
- bioRxiv. 2026 Jun 30:2026.06.29.733236.
- bioRxiv. 2026 May 25.
- Vasc Endovasc Rev. 2025 Nov 7.
- Biomed Pharmacother. 2025 Nov:192:118665. [Abstract]
- J Nephropharmacol. 2025 Sep 20:e12798
- World J Methodol. 2025 Jun 20;15(2):99580. [Abstract]
- bioRxiv. 2024 November 08.
Customer Validation & Images
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Bio/Physico-chemical Assay
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WB
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
生物活性
製品説明
IC50 & Target
体内実験
Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Calcium (VLDL) in diabetes mellitus rats induced by Streptozocin[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 147098-20-2
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性状 Solid
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分子量 500.57
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分子式 C22H27Ca0.5FN3O6S
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Color White to off-white
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SMILES
O=C([O-])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2.[0.5Ca2+]
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別名
Rosuvastatin (Calcium); Rosuvastatin hemicalcium; ZD 4522 Calcium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
Publications (29)
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Journal Impact Factor
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Most Recent
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Cell Metab
Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development. [Abstract]2025 Sep 2;37(9):1907-1925.e14. PMID: 40803319 -
Adv Sci (Weinh)
Short-Term Statin Therapy Induces Hepatic Insulin Resistance Through HNF4α/PAQR9/PPM1α Axis Regulated AKT Phosphorylation. [Abstract]2024 Sep;11(34):e2403451. PMID: 38970167
Rosuvastatin Calcium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]
Western blotting of PAQR9 in mouse primary hepatocytes under the treatment of DMSO, simvastatin (Sim), atorvastatin (Ator), and rosuvastatin (Rosu) (10 μM; 24–48 h) was performed.
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MedComm (2020)
Statins, but not proprotein convertase subtilisin-kexin type 9 inhibitors, lower chemerin in hypercholesterolemia via low-density lipoprotein receptor upregulation. [Abstract]2024 Aug 31;5(9):e681. PMID: 39220103
Rosuvastatin Calcium purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2024 Aug 31;5(9):e681. [Abstract]
Chemerin levels in the medium of HepG2 cells cultured for 48 h, in the absence (control) or presence of atorvastatin, evolocumab, or Rosuvastatin, were measured.
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Biosens Bioelectron
Drug functionalized organic electromechanical transistor for rapid and sensitive detection of C-reactive protein. [Abstract]2025 Nov 15:288:117807. PMID: 40712486 -
Phytomedicine
Theaflavin-3,3'-digallate stabilizes vulnerable plaques by reprogramming metabolic homeostasis in neovascularization via HK2/TIGAR. [Abstract]2025 Sep:145:157014. PMID: 40570559 -
Phytomedicine
Gut microbiome and metabolomic profiles reveal the antiatherosclerotic effect of indole-3-carbinol in high-choline-fed ApoE-/- mice. [Abstract]2024 Jul:129:155621. PMID: 38678950 -
Cell Death Discov
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing. [Abstract]2024 May 29;10(1):263. PMID: 38811564
Rosuvastatin Calcium purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 May 29;10(1):263. [Abstract]
Rosuvastatin calcium (5 mg/kg i.p.) was administered. Images of the wound area in the rosuvastatin calcium-treated group and the control group were captured.
Rosuvastatin Calcium purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 May 29;10(1):263. [Abstract]
Rosuvastatin calcium (5 mg/kg i.p.) was administered. The free cholesterol level of skin tissue after rosuvastatin calcium treatment for 12 days was measured. Each experiment was replicated at least thrice and representative images were shown.
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Acta Pharmacol Sin
2023 Jul;44(7):1416-1428. PMID: 36721007
Rosuvastatin Calcium purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 Jul;44(7):1416-1428. [Abstract]
Rosuvastatin calcium (10 mg/kg body weight every second day, n = 5) was administered. The body weights of control and bavachin-treated mice were measured weekly from weeks 1 to 20.
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Free Radic Biol Med
Rosuvastatin ameliorates high-altitude cerebral edema by promoting blood-brain barrier integrity via the regulation of energy metabolism. [Abstract]2026 Jun 24:254:360-369. PMID: 42341957 -
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Front Bioeng Biotechnol
Application of 3D Hepatic Plate-Like Liver Model for Statin-Induced Hepatotoxicity Evaluation. [Abstract]2022 Mar 17;10:826093. PMID: 35372314 -
Eur J Pharmacol
Combining idebenone and rosuvastatin prevents atherosclerosis by suppressing oxidative stress and NLRP3 inflammasome activation. [Abstract]2023 Sep 15:955:175911. PMID: 37451421 -
Front Cell Dev Biol
Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis. [Abstract]2022 Mar 3;10:806081. PMID: 35309902 -
Front Cell Dev Biol
2021 May 6;9:651579. PMID: 34026753 -
ACS Omega
Association Study of OATP1B3 Polymorphisms on Hepatic Uptake and Drug-Drug Interaction In Vitro. [Abstract]2025 Oct 29;10(44):52562-52575. PMID: 41244417 -
Cell Signal
Rosuvastatin inhibits carcinogenesis through Ca2+ triggered endoplasmic reticulum stress pathway in pancreatic cancer. [Abstract]2025 Jul:131:111753. PMID: 40107481 -
J Inflamm Res
Rosuvastatin Enhances Alveolar Fluid Clearance in Lipopolysaccharide-Induced Acute Lung Injury by Activating the Expression of Sodium Channel and Na,K-ATPase via the PI3K/AKT/Nedd4-2 Pathway. [Abstract]2021 Apr 16:14:1537-1549. PMID: 33889010 -
FASEB J
Simvastatin Restores Cisplatin Sensitivity by Suppressing the Caveolin-1-Mediated PI3K/AKT Signaling Pathway in Cisplatin-Resistant Cervical Cancer Cells. [Abstract]2026 May 15;40(9):e71873. PMID: 42087353 -
Pharm Res
Profiling Interactions Between Bicyclol and SLC/ABC Transporters: Advancing Clinical Safety and Efficacy in Combination Therapy. [Abstract]2025 Oct 27. PMID: 41145746 -
Front Oncol
Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor. [Abstract]2021 May 10:11:595285. PMID: 34041015 -
PLoS One
Rosuvastatin protects against oxLDL-induced endothelial cell oxidative stress and attenuates atherosclerotic plaque formation in ApoE-/- mice through the NF-κB pathway. [Abstract]2026 Feb 20;21(2):e0339967. PMID: 41719299 -
Exp Ther Med
Rosuvastatin protects PC12 cells from hypoxia/reoxygenation-induced injury by inhibiting endoplasmic reticulum stress-induced apoptosis. [Abstract]2021 Oct;22(4):1189. PMID: 34475979 -
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Biomed Pharmacother
Integrated pharmacokinetic properties and tissue distribution of Corydalis saxicola Bunting total alkaloids in HFHCD-induced mice: Implications for pharmacokinetic variability in MASH treatment. [Abstract]2025 Nov:192:118665. PMID: 41124864 -
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World J Methodol
Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy. [Abstract]2025 Jun 20;15(2):99580. PMID: 40548212 -
溶剤 & 溶解度
体外:
DMSO : 25 mg/mL (49.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (2.00 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (278 KB)
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SDS (537 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [Content Brief]
[2]. Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. [Content Brief]
[3]. Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78. [Content Brief]
[4]. Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.9977 mL | 9.9886 mL | 19.9772 mL | 49.9431 mL |
| DMSO | 5 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL | 9.9886 mL |
| 10 mM | 0.1998 mL | 0.9989 mL | 1.9977 mL | 4.9943 mL | |
| 15 mM | 0.1332 mL | 0.6659 mL | 1.3318 mL | 3.3295 mL | |
| 20 mM | 0.0999 mL | 0.4994 mL | 0.9989 mL | 2.4972 mL | |
| 25 mM | 0.0799 mL | 0.3995 mL | 0.7991 mL | 1.9977 mL | |
| 30 mM | 0.0666 mL | 0.3330 mL | 0.6659 mL | 1.6648 mL | |
| 40 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2486 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Rosuvastatin Calcium 関連分類
HY-17504 関連分類
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