SA 47
Based on 1 publication(s) in Google Scholar
SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. SA 47 inhibits FAAH enzyme activity and disrupts the NLRP3-FAAH interaction, promoting K48 ubiquitination and selective autophagic degradation of NLRP3. SA 47 reduces NLRP3 protein levels in macrophages. SA 47 can be used for research on inflammatory diseases associated with NLRP3 protein mutations.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.0%
- CAS 番号: 792236-07-8
- 分子式: C17H26N4O3
- 分子量:334.41
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 SA 47
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生物活性
製品説明
IC50 & Target
FAAH, Carbamate[1].
体外実験
SA 47 (40 μM) induces NLRP3 protein degradation in BMDMs, reducing NLRP3 protein levels by more than 30%[1].
SA 47 (10 μM; 30 min) does not inhibit any of the seven cloned rat carboxylesterases in HEK293T cells (X51974/TGH/ES10, NM_031565/ES3, NM_133586/ES2, NM_144743, NM_017004, X81825/ES4, and NM_001024365)[2].
SA 47 (10 μM; 30 min) does not significantly inhibit carboxylesterase activity in rat liver microsomes or cytosol[2].
SA 47 shows excellent selectivity for FAAH in both mouse and human tissues, with no significant off-target effects at 10 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 792236-07-8
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性状 Solid
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分子量 334.41
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分子式 C17H26N4O3
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Color White to off-white
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SMILES
CNC(COC(NCCC(CC1)CCN1C2=CC=CC(C)=N2)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Differ
FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. [Abstract]2023 Jan;30(1):168-183. PMID: 36104448
プロトコル
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Autophagy
Autophagy is a process in which eukaryotic cells use lysosomes to degrade their own cytoplasmic proteins and damaged organelles under the regulation of autophagy related gene (Atg). Microtubule-associated proteins light chain 3 (LC3) is recognized as autophagy marker, which transfers from cytoplasmic LC3 (LC3-I) to membrane type (LC3-II). LC3-II/I ratio could be detected by Western Blot and fluorescence microscopy.
純度とドキュメンテーション
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データシート (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SA 47 関連分類
HY-18080 関連分類
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