AA29504
AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases .
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 945828-50-2
- 分子式: C19H25N3O2
- 分子量:327.42
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
AA29504 (0.1, 1, 10, 100 μM, 72 h) can open the Kv7 voltage-gated K+ channels (KCNQ) in Xenopus oocytes [1].
AA29504 (1 μM) positively regulates GABAA receptors expressed in Xenopus oocytes, EC501.4 μM[1] .
AA29504 (1 μM, 10 s) significantly enhances the gaboxadol-mediated current in pyramidal neurons of the prefrontal cortex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AA29504 (4 mg/kg, subcutaneous injection) significantly weakenes the motor coordination of male SD rats under the synergistic effect of alcohol [1].
AA29504 (2.5, 5 and 10 mg/kg, subcutaneously injection) has therapeutic effect on amygdala ignited seizures in male Wistar rats [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Spraguee Dawley rats [1]
-
Dosage:0.5, 2 or 4 mg/kg
-
Administration:Subcutaneous injections
-
Result:Reduced the number of vocalizations at 4 mg/kg and reversed partially the freezing behavior at 2 mg/kg.
-
Animal Model:Male Spraguee Dawley rats [1]
-
Dosage:4 mg/kg
-
Administration:Subcutaneous injections
-
Result:Reduced the time the rats stayed on the rotarod at 4 mg/kg.
-
Animal Model:Male Wistar rats [1]
-
Dosage:10 mg/kg
-
Administration:Subcutaneous injections
-
Result:Reduced from 4.9 to 2.0 in amygdala kindled seizures response.
化学情報
-
CAS 番号 945828-50-2
-
分子量 327.42
-
分子式 C19H25N3O2
-
SMILES
O=C(NC1=CC=C(NCC2=C(C)C=C(C)C=C2C)C=C1N)OCC
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
-
データシート (271 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AA29504 関連分類
HY-103522 関連分類
Powered by Bioz