AA76-lipid
AA76-lipid (Compound aa76) is a compound with a C-terminal arginine and histidine. AA76-lipid can be used to prepare pancreas-targeted lipid nanoparticles AH-LNP. After assembling with proteins, the increased size of AH-LNP promotes Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, thereby enhancing pancreas-targeting ability. AA76-lipid enables highly pancreas-selective delivery of mRNA. AA76-lipid can be used in the research of pancreatic cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C55H101N9O6
- 分子量:984.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in rats, rabbits, dogs, and pigs, with nearly 90% of bioluminescence signal localized to the pancreas[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 984.45
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分子式 C55H101N9O6
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SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCCN(CCOC(CCCCCCC/C=C\CCCCCCCC)=O)CCCNC([C@H](CC1=CNC=N1)NC([C@@H](N)CCCNC(N)=N)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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