AA76-lipid
Based on 1 Customer Validation
AA76-lipid (Compound aa76) is a compound with a C-terminal arginine and histidine. AA76-lipid can be used to prepare pancreas-targeted lipid nanoparticles AH-LNP. After assembling with proteins, the increased size of AH-LNP promotes Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, thereby enhancing pancreas-targeting ability. AA76-lipid enables highly pancreas-selective delivery of mRNA. AA76-lipid can be used in the research of pancreatic cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.80%
- 分子式: C55H101N9O6
- 分子量:984.45
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in rats, rabbits, dogs, and pigs, with nearly 90% of bioluminescence signal localized to the pancreas[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 984.45
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分子式 C55H101N9O6
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Color White to off-white
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SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCCN(CCOC(CCCCCCC/C=C\CCCCCCCC)=O)CCCNC([C@H](CC1=CNC=N1)NC([C@@H](N)CCCNC(N)=N)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (101.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 100 mg/mL (101.58 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.0158 mL | 5.0790 mL | 10.1580 mL | 25.3949 mL |
| 5 mM | 0.2032 mL | 1.0158 mL | 2.0316 mL | 5.0790 mL | |
| 10 mM | 0.1016 mL | 0.5079 mL | 1.0158 mL | 2.5395 mL | |
| 15 mM | 0.0677 mL | 0.3386 mL | 0.6772 mL | 1.6930 mL | |
| 20 mM | 0.0508 mL | 0.2539 mL | 0.5079 mL | 1.2697 mL | |
| 25 mM | 0.0406 mL | 0.2032 mL | 0.4063 mL | 1.0158 mL | |
| 30 mM | 0.0339 mL | 0.1693 mL | 0.3386 mL | 0.8465 mL | |
| 40 mM | 0.0254 mL | 0.1270 mL | 0.2539 mL | 0.6349 mL | |
| 50 mM | 0.0203 mL | 0.1016 mL | 0.2032 mL | 0.5079 mL | |
| 60 mM | 0.0169 mL | 0.0846 mL | 0.1693 mL | 0.4232 mL | |
| 80 mM | 0.0127 mL | 0.0635 mL | 0.1270 mL | 0.3174 mL | |
| 100 mM | 0.0102 mL | 0.0508 mL | 0.1016 mL | 0.2539 mL |
AA76-lipid 関連分類
HY-185260 関連分類
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