Albicidin
Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1622253-00-2
- 分子式: C44H38N6O12
- 分子量:842.81
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
MoreTopoisomerase アイソフォーム固有の製品をすべて表示
MoreDNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
[1]|
DNA Gyrase |
体外実験
Albicidin (30-200 nM) inhibits the DNA gyrase supercoiling activity of E. coli, with an IC50 of approximately 40 nM[1].
Albicidin exhibits potent antibacterial activity against Escherichia coli (including fluoroquinolone-resistant strains), Salmonella enteritidis, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus, with MIC values ranging from 0.031 to 16 μg/mL[1].
Albicidin (0-3200 nM; 30-60 min) inhibits DNA supercoiling mediated by wild-type E. coli DNA gyrase, with an IC50 of 40 nM[2].
Albicidin (0-1600 nM; 30-60 min) inhibits the DNA supercoiling activity of mitochondrial and chloroplast DNA gyrases in Arabidopsis thaliana, with an IC50 of 50 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1622253-00-2
-
分子量 842.81
-
分子式 C44H38N6O12
-
SMILES
O=C(C1=C(C(OC)=C(C=C1)NC(C2=CC=C(C=C2)NC([C@H](CC#N)NC(C3=CC=C(C=C3)NC(/C(C)=C/C4=CC=C(C=C4)O)=O)=O)=O)=O)O)NC5=C(C(O)=C(C=C5)C(O)=O)OC
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kretz J, et al. Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors. Angew Chem Int Ed Engl. 2015;54(6):1969-1973. [Content Brief]
[2]. Hashimi SM, et al. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother. 2007;51(1):181-187. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Albicidin 関連分類
HY-108988 関連分類
Powered by Bioz
Keywords