Alloc-Val-Ala-pAB
Based on 1 Customer Validation
Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.02%
- CAS 番号: 1343407-91-9
- 分子式: C19H27N3O5
- 分子量:377.43
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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Help & FAQs
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HY-136136
Fmoc-Val-Ala-PAB-PNP
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HY-135975
MC-Val-Ala-PAB-PNP
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HY-126364
Mc-Val-Ala-PAB
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HY-130932
Boc-Val-Ala-PAB-PNP
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HY-126353
Fmoc-Val-Ala-PAB-OH
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HY-125933
Val-Ala-PAB
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HY-136547
Boc-Val-Ala-PAB
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HY-20336
Mc-Val-Cit-PABC-PNP
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HY-12362
Val-cit-PAB-OH
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HY-41189
Fmoc-Val-Cit-PAB-PNP
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HY-W106311
Fmoc-Val-Ala-OH
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HY-W591374
DBCO-PEG4-Val-Ala-PAB-PNP
生物活性
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1343407-91-9
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性状 Solid
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分子量 377.43
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分子式 C19H27N3O5
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Color Off-white to gray
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SMILES
OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCC=C)=O)C(C)C)=O)C)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 10 mg/mL (26.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (241 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6495 mL | 13.2475 mL | 26.4950 mL | 66.2374 mL |
| 5 mM | 0.5299 mL | 2.6495 mL | 5.2990 mL | 13.2475 mL | |
| 10 mM | 0.2649 mL | 1.3247 mL | 2.6495 mL | 6.6237 mL | |
| 15 mM | 0.1766 mL | 0.8832 mL | 1.7663 mL | 4.4158 mL | |
| 20 mM | 0.1325 mL | 0.6624 mL | 1.3247 mL | 3.3119 mL | |
| 25 mM | 0.1060 mL | 0.5299 mL | 1.0598 mL | 2.6495 mL |
Alloc-Val-Ala-pAB 関連分類
HY-W071967 関連分類
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