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United States

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製品番号: HY-P11768

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AMBA

AMBA is a gastrin-releasing peptide receptor (GRPR, BB2, BRS-2) ligand. AMBA binds to GRPR with high specificity and high affinity, and undergoes receptor-mediated endocytosis, which retains the conjugated radiometal in target cells. AMBA is applicable for the research of prostate cancer.

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CAS 番号: 721937-56-0
分子式: C₆₈H₉₉N₁₉O₁₈S
分子量:1502.70

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

AMBA 構造式

CAS 番号: 721937-56-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

AMBA (0.001-1000 nmol/L; 60 min) exhibits high specificity and nanomolar affinity for human GRPR receptors, with an IC₅₀ of 0.82 nmol/L and a K_i of 0.65nmol/L^[1].
AMBA (6.66 × 10^-4 μmol (1 μg); 10 min) can be efficiently radiolabeled with ¹¹¹In, achieving a radiolabeling efficiency of 95.43% under the tested conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

¹¹¹In-AMBA (0.37 MBq-12.2 MBq/4 μg; i.v.; single dose) achieves peak tumor uptake of 3.87 ± 0.65% ID/g at 8 hours post-injection in PC-3 prostate tumor-bearing SCID mice, with a maximum tumor/muscle ratio of 11.79, demonstrating effective targeting of GRPR-expressing tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 721937-56-0
分子量 1502.70
分子式 C₆₈H₉₉N₁₉O₁₈S
配列

{DOTA}-Gly-{PAB}-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
シーケンスの短縮

{DOTA}-G-{PAB}-QWAVGHLM-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ho CL, et al. Molecular imaging, pharmacokinetics, and dosimetry of In-AMBA in human prostate tumor-bearing mice. J Biomed Biotechnol. 2011;2011:101497. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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