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United States

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製品番号: HY-189264

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Anticancer agent-362

Anticancer agent-362 is a chimeric pyrrolidinedione-pyrrolidine-phthalazine-triazole (PPPT) heterocyclic derivative with antitumor activity. Anticancer agent-362 exhibits antiproliferative activity against breast adenocarcinoma and osteosarcoma cancer cell lines, with low toxicity to normal fibroblasts. Anticancer agent-362 is predicted to be a multi-target ligand that binds to the active sites of VEGFR-2, PARP-1, and others. Anticancer agent-362 can be used in research related to breast adenocarcinoma and osteosarcoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₈H₂₂N₆O₄S
分子量:538.58

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent-362 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HOS	IC50	335.74 μM	Cytotoxicity against human osteosarcoma HOS cells assessed as reduction in cell viability using a seven-point concentration-response MTT assay. Cytotoxicity against human osteosarcoma HOS cells assessed as reduction in cell viability using a seven-point concentration-response MTT assay.	j.bioorg.2026.110413
MCF7	IC50	222.81 μM	Cytotoxicity against human breast adenocarcinoma MCF7 cells assessed as reduction in cell viability using a seven-point concentration-response MTT assay. Cytotoxicity against human breast adenocarcinoma MCF7 cells assessed as reduction in cell viability using a seven-point concentration-response MTT assay.	j.bioorg.2026.110413
MG-63	IC50	271.12 μM	Cytotoxicity against human osteosarcoma MG-63 cells assessed as reduction in cell viability using a seven-point concentration-response MTT assay. Cytotoxicity against human osteosarcoma MG-63 cells assessed as reduction in cell viability using a seven-point concentration-response MTT assay.	j.bioorg.2026.110413

体外実験

Anti-cancerOthers

Anti-cancer

Anticancer agent-362 (compound 6J) (10-50 µM; 24 h) exhibits low toxicity toward normal HDF fibroblasts and shows excellent to moderate anticancer activity against MCF7, HOS, and MG-63 cancer cell lines^[1].
Anticancer agent-362 has an IC₅₀ = 431.29 μM against normal human dermal fibroblasts HDF, an IC₅₀ = 335.74 μM against osteosarcoma HOS cells, an IC₅₀ = 222.81 μM against breast cancer MCF7 cells, and an IC₅₀ = 271.12 μM against osteosarcoma MG‑63 cells^[1].

Others

Anticancer agent-362 is predicted to act as a multi-target ligand that binds to the active pockets of VEGFR-2 and PARP-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF7, HOS, and MG-63 cancer cell lines
Concentration:

10, 50 µM
Incubation Time:

24 h
Result:

Demonstrated low toxicity against normal HDF fibroblasts and exhibits very good to moderate anticancer activity against MCF7, HOS, and MG-63 cancer cell lines.

Related Protocols :

化学情報

分子量 538.58
分子式 C₂₈H₂₂N₆O₄S
SMILES

O=C1N(C2=CC=CC=C2)C([C@@]3([H])[C@]1([H])[C@H](C4=CN(S(=O)(C5=CC=C(C)C=C5)=O)N=N4)N6[C@@]3([H])C7=C(C=CC=C7)C=N6)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Savu M, et al. Chimeric pyrrolodiketo-pyrrolidine-phthalazine – triazole derivatives: synthesis, structure, stereochemistry, and anticancer activity. Bioorganic Chemistry, 2026, 181: 110413.

Calculators

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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