Antimalarial agent 50
Antimalarial agent 50 is an antiplasmodial compound. Antimalarial agent 50 has an effect against Plasmodium berghei induced malaria infection in mice model. Antimalarial agent 50 can regulate oxidative stress and significantly reduce the levels of inflammatory factors. Antimalarial agent 50 can be used for the research of the malaria.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2384242-67-3
- 分子式: C24H18N4OS
- 分子量:410.49
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Parasite アイソフォーム固有の製品をすべて表示
More
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:P. berghei NK 65 strain injected male Balb/c mice model (6-8 weeks)[1].
-
Dosage:200-800 μg/kg, Positive control group Chloroquine (HY-17589A)
-
Administration:Intraperitoneal injection (i.p.)
-
Result:Showed the best anti parasitemia effect at 800 µg/kg with the inhibition rate of 83.6 %.
Restored RBCs similar to the vehicle control group.
Improved the condition of the ruffled fur and anxiety.
Significantly reversed RBCs, Hb, PCV, MCV, MCH, MCHC and platelets of infected mice.
Significantly reduced the concentration of AST, ALP, ALT and bilirubin, creatinine, uric acid and improved the pathological structure of the liver and spleen.
Improved the concentration of GSH, GST and CAT and reduced the concentration of NO and MDA.
Restored blood sugar levels in the infected mice.
Reduced the level of inflammatory factors NF-κB, IL-6, IFN-γ and decreased the level of the TNF-α, iNOS, IL-1β
化学情報
-
CAS 番号 2384242-67-3
-
分子量 410.49
-
分子式 C24H18N4OS
-
SMILES
O=C(N1N=C(C2=CC=CC=C2)C=C1C3=CC=CC=C3)CSC4=NC5=CC=CC=C5N4
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimalarial agent 50 関連分類
HY-174325 関連分類
Powered by Bioz