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United States

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製品番号: HY-178436

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Antituberculosis agent-16

Antituberculosis agent-16 is an orally active antituberculosis agent. Antituberculosis agent-16 exhibits stable antituberculosis activity with a MIC of 0.48 μg/mL against Mycobacterium tuberculosis H37Rv sensitive strain and 0.49 μg/mL against multidrug-resistant strain 14862. Antituberculosis agent-16 shows high Caco-2 permeability. Antituberculosis agent-16 can be used for the research of infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₃H₂₉N₃O₃
分子量:395.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antituberculosis agent-16 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Antituberculosis agent-16 shows low cytotoxicity to Vero cells with an IC₅₀ of 37.14 μg/mL^[1].
Antituberculosis agent-16 has high cell membrane permeability with an apparent permeability coefficient (Papp) of 46.1×10^-6 cm/s in Caco-2 assay^[1].
Antituberculosis agent-16 (1-10 μg/mL, 72 h) dose-dependently reduces the intracellular Mycobacterium tuberculosis load in mouse J774A.1 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_1/2	MRT_0-t	MRT_0-∞	AUC_0-t	AUC_0-∞	T_max	F
Mice^[1]	5 mg/kg	i.v.	9289 ng/mL	0.22 h	0.2 h	0.2 h	1333 ng·h/mL	1339 ng·h/mL	/	/
Mice^[1]	50 mg/kg	p.o.	923 ng/mL	2.17 h	2.46 h	3.44 h	3480 ng·h/mL	3944 ng·h/mL	0.5-1 ng/mL	29.5 %

化学情報

分子量 395.49
分子式 C₂₃H₂₉N₃O₃
SMILES

O=C(C1=CC(C2=CC(OCCOC)=NC=C2)=CN1)N[C@H]3C4CC5C[C@@H](C4)C[C@H]3C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wu Y, et al. Optimization of pyrrole-2-carboxamide to develop a potent antituberculosis agent with improved physicochemical property and druggability. Bioorg Chem. 2025 Oct;165:109016. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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