CCF1
CCF1 is a carbon-rhodol-based turn-on fluorescent copper sensor with high selectivity for Cu+ over other biologically relevant metal ions. CCF1 detects changes in labile copper pools in living cells upon copper supplementation and/or depletion. CCF1 identifies elevations in labile copper pools in Atp7a-/- fibroblast cell models. CCF1 can be used for the research of Menkes disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2158208-42-3
- 分子式: C40H51F3N2O2S4
- 分子量:777.10
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
CCF1 is a fluorescent sensor with Cu+ selectivity in aqueous buffer at physiological pH, which produces a 5-fold fluorescence turn-on response with an apparent Cu+-binding Kd of 0.20 pM[1].
CCF1 (2 μM; 15 min) detects increased and decreased levels of labile copper pools in live HEK 293T cells, with enhanced fluorescence under copper supplementation conditions and reduced fluorescence under copper depletion conditions[1].
CCF1 (2 μM; 10 min) detects elevated levels of labile copper pools in live Atp7a-/- MEFs relative to wild-type MEF controls[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2158208-42-3
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分子量 777.10
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分子式 C40H51F3N2O2S4
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SMILES
CCSCCSCCN(CC1=CC=C(C(C(F)(F)F)=C1)C2=C3C=CC(C=C3C(C)(C4=C2C=CC(N5CCOCC5)=C4)C)=O)CCSCCSCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CCF1 関連分類
HY-D3282 関連分類
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