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United States

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製品番号: HY-187179

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CDK2-IN-62

CDK2-IN-62 is a predicted CDK2 inhibitor. CDK2-IN-62 induces apoptosis in breast cancer cells and reduces their colony-forming ability. CDK2-IN-62 can be used for the research of breast cancer, ovarian cancer and colorectal cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₇H₂₁N₃O₂S
分子量:451.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK2-IN-62 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

human CDK2

CDK アイソフォーム固有の製品をすべて表示 :

体外実験

CDK2-IN-62 (Compound 4e) (48 h) inhibits the viability of MCF-7, A2780cis and HT-29 cells with IC₅₀ values of 9.19, 8.21 and 18.84 μM, respectively; it shows low toxicity to normal CHO epithelial cells^[1].
CDK2-IN-62 (9.19 μM; 48 h) inhibits clonal proliferation of human breast cancer MCF-7 cells^[1].
CDK2-IN-62 (9.19 μM; 36 h) induces apoptosis in MCF-7 human breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

9.19 μM
Incubation Time:

36 h
Result:

Increased the total percentage of apoptotic MCF-7 cells (early + late apoptosis) to 53.1%, up from 4.22% in control cells; necrotic cells accounted for 18.5% of treated cells.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7 human breast cancer cells
Concentration:

9.19 μM
Incubation Time:

48 h
Result:

Significantly reduced the number of colonies formed by MCF-7 cells compared to the control group.

化学情報

分子量 451.54
分子式 C₂₇H₂₁N₃O₂S
SMILES

N#CC1=C(N)OC(C)=C(SC2=CC=CC=C2)C31C(N(CC4=CC=CC=C4)C5=C3C=CC=C5)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Jamshidi Z, et al. Multicomponent synthesis of novel spiro-indoline-3,4'-pyran derivatives: in silico and in vitro study. Sci Rep. 2026 Jun 27.
[Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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CDK2-IN-62

CDK アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CDK2-IN-62 関連分類

HY-187179 関連分類

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