country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-W563489

Copy Link Print Information

Clomoxir

Name: Clomoxir
Brand: MedChemExpress
SKU: HY-W563489
Availability: PreOrder

(別名: POCA)

Clomoxir (POCA) is a carnitine palmitoyltransferase I (CPT I) inhibitor with hypoglycemic activity. Clomoxir mediates the inhibition of CPT I via its active form POCA-CoA. Clomoxir inhibits long-chain fatty acid oxidation, ketogenesis, gluconeogenesis, de novo synthesis of cholesterol and fatty acids, and also mildly inhibits acetyl-CoA carboxylase. Clomoxir reduces blood glucose levels in various rodent and porcine models, alters plasma NEFA and cholesterol concentrations, induces hepatic lipid accumulation, peroxisome proliferation and mild myocardial hypertrophy in rats, and stimulates the pentose phosphate pathway in cultured human fibroblasts. Clomoxir can be used in diabetes-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 88431-47-4
分子式: C₁₄H₁₇ClO₃
分子量:268.74

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clomoxir 構造式

CAS 番号: 88431-47-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

CPT-1

体外実験

Clomoxir (POCA) exerts multiple metabolic regulatory effects: its coenzyme A ester metabolite inhibits the activity of carnitine palmitoyltransferase in rat liver mitochondria; it suppresses de novo synthesis of cholesterol and fatty acids in the liver, and blocks lactate- and pyruvate-mediated gluconeogenesis stimulated by oleic acid; it activates the pentose phosphate pathway in human fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Clomoxir (POCA) (200 mg/kg; daily; 3 months) lowers blood glucose and inhibits fatty acid oxidation, ketogenesis, gluconeogenesis, and de novo lipid synthesis in multiple diabetic animal models, though high-dose chronic administration causes liver lipid accumulation, peroxisome proliferation, and mild cardiac hypertrophy in rats^[1].
Clomoxir lowers plasma NEFA and cholesterol concentrations by approximately 50% in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 88431-47-4
分子量 268.74
分子式 C₁₄H₁₇ClO₃
SMILES

O=C(O)C1(OC1)CCCCCC2=CC=C(Cl)C=C2
別名

POCA
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Foley JE, et al. Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus. Diabetes care. 1992 Jun;15(6):773-84.

[2]. Agius L, et al. Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochemical pharmacology. 1991 Oct 09;42(9):1717-20.

[3]. Spurway TD, et al. Etomoxir, sodium 2-[6-(4-chlorophenoxy)hexyl] oxirane-2-carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes. FEBS letters. 1997 Mar 03;404(1):111-4.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ