Denopterin
Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an antimetabolite that has toxic effects on cells and can be used for cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 22006-84-4
- 分子式: C21H23N7O6
- 分子量:469.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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VHL |
Antibody-drug conjugates (ADCs) have great promise as anti-cancer drugs. In recent years, there has been increasing applications of the pyrrolobenzo-diazepine dimer (PBD) class of cytotoxic payloads as ADC therapeutics due to PBDs’extream potency against most of the US National Cancer Institute’s (NCI’s) NCI 60-tumor-cell line panels along with unique mechanism of antitumor antibiotics activity. All PBDs are usually conjugated to an antibody with one conditionally stable linker, because it is normally believed that linkers of ADCs must be stable while the ADC is circulating in the blood to limit off-target toxicity, but allow for release of the drug once it is inside the target cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 22006-84-4
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分子量 469.45
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分子式 C21H23N7O6
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SMILES
O=C1C2=NC(C(C)N(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C)=CNC2=NC(N)=N1
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別名
Pteroylglutamic acid
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Denopterin 関連分類
HY-121207 関連分類
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