country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

NOSTRIN - nitric oxide synthase trafficking Gene

Also Known as DaIP2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 115677

About NOSTRIN

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,786,539-168,865,514 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 176 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 8.2), lung (RPKM 6.6) and 24 other tissues.

Summary

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO Synthase (ENOS; MIM 163729), and triggers the translocation of eNOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

NOSTRIN Products (4)

mRNA	Protein	Name
NM_001039724.4	NP_001034813.2	nostrin isoform 2
NM_001171631.2	NP_001165102.1	nostrin isoform 4
NM_001171632.2	NP_001165103.1	nostrin isoform 3
NM_052946.4	NP_443178.2	nostrin isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	12446846	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOSTRIN Protein Structure

FCH

SH3_1

0
100
200
300
400
506 a.a.

Protein Preferred Names	Protein Names
nostrin	BM247 homolog

NOSTRIN Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	NOSTRIN	Q8IVI9	FGFR1	Homo sapiens	P11362	Y2H	22751148
Intra	NOSTRIN	Q8IVI9	FGFR1	Homo sapiens	P11362	Pull Down	22751148
Intra	NOSTRIN	Q8IVI9	NOS3	Homo sapiens	P29474	Anti Tag CoIP	16234328
Intra	NOSTRIN	Q8IVI9	NOS3	Homo sapiens	P29474	Confocal	12446846
Intra	NOSTRIN	Q8IVI9	NOS3	Homo sapiens	P29474	Pull Down	16234328
Intra	NOSTRIN	Q8IVI9	NOS3	Homo sapiens	P29474	Y2H	12446846
Intra	NOSTRIN	Q8IVI9	NOS3	Homo sapiens	P29474	Anti Bait CoIP	12446846
Intra	NOSTRIN	Q8IVI9	DNM1	Homo sapiens	Q05193	Pull Down	16234328
Cross	NOSTRIN	Q8IVI9	Wasl	Rattus norvegicus	O08816	Pull Down	16234328
Cross	NOSTRIN	Q8IVI9	Wasl	Rattus norvegicus	O08816	Anti Tag CoIP	16234328

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Eclampsia	Eclampsia In Puerperium Postpartum Eclampsia Eclampsia, Postpartum Puerperal Eclampsia
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS09444	NOSTRIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	NOSTRIN	MGD	MGI:3606242
Canis familiaris	NOSTRIN	VGNC	VGNC:43897
Rattus norvegicus	NOSTRIN	RGD	RGD:727920
Macaca mulatta	NOSTRIN	VGNC	VGNC:75219
Bos taurus	NOSTRIN	VGNC	VGNC:32176
Felis catus	NOSTRIN	VGNC	VGNC:63862
Others	NOSTRIN	NCBI