NOSTRIN - nitric oxide synthase trafficking Gene

Also Known as DaIP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115677

About NOSTRIN

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:168,786,539-168,865,514 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 176 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 8.2), lung (RPKM 6.6) and 24 other tissues.

Summary

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO Synthase (ENOS; MIM 163729), and triggers the translocation of eNOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

NOSTRIN Products (4)

mRNA Protein Name
NM_001039724.4 NP_001034813.2 nostrin isoform 2
NM_001171631.2 NP_001165102.1 nostrin isoform 4
NM_001171632.2 NP_001165103.1 nostrin isoform 3
NM_052946.4 NP_443178.2 nostrin isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12446846 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOSTRIN Protein Structure

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (14 - 92)

SH3_1

SH3_1: SH3 domain (444 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 506 a.a.
Protein Preferred Names Protein Names

nostrin

  • BM247 homolog

NOSTRIN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NOSTRIN Q8IVI9 FGFR1 Homo sapiens P11362
Y2H
22751148
Intra
NOSTRIN Q8IVI9 FGFR1 Homo sapiens P11362
Pull Down
22751148
Intra
NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Anti Tag CoIP
16234328
Intra
NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Confocal
12446846
Intra
NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Pull Down
16234328
Intra
NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Y2H
12446846
Intra
NOSTRIN Q8IVI9 NOS3 Homo sapiens P29474
Anti Bait CoIP
12446846
Intra
NOSTRIN Q8IVI9 DNM1 Homo sapiens Q05193
Pull Down
16234328
Cross
NOSTRIN Q8IVI9 Wasl Rattus norvegicus O08816
Pull Down
16234328
Cross
NOSTRIN Q8IVI9 Wasl Rattus norvegicus O08816
Anti Tag CoIP
16234328
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Eclampsia

  • Eclampsia In Puerperium

  • Postpartum Eclampsia

  • Eclampsia, Postpartum

  • Puerperal Eclampsia
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09444 NOSTRIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NOSTRIN MGD MGI:3606242
Canis familiaris NOSTRIN VGNC VGNC:43897
Rattus norvegicus NOSTRIN RGD RGD:727920
Macaca mulatta NOSTRIN VGNC VGNC:75219
Bos taurus NOSTRIN VGNC VGNC:32176
Felis catus NOSTRIN VGNC VGNC:63862
Others NOSTRIN NCBI