Ccr8 - chemokine (C-C motif) receptor 8 Gene

Also Known as C-C; CCR-8; CKR-8; mCCR8; Cmkbr8; CC-CKR-8; C-C CKR-8

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 12776

About Ccr8

Chromosome 9: 119,921,180-119,923,972 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 236 orthologues, 25 paralogues and is associated with 7 phenotypes. Biased expression in thymus adult (RPKM 6.3), mammary gland adult (RPKM 1.1) and 3 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Acts upstream of or within chemotaxis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; retina; and Thymus primordium. Orthologous to human CCR8 (C-C motif Chemokine Receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Ccr8 Products (1)

mRNA Protein Name
NM_007720.2 NP_031746.1 C-C chemokine receptor type 8

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables C-C chemokine receptor activity IDA
IDA: Inferred from direct assay
9670926 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9670926 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within chemotaxis IDA
IDA: Inferred from direct assay
9670926 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr8 Protein Structure

7tmA_CCR8

7tmA_CCR8: cd15187 (33 - 308)

7tmA_CCR8

7tmA_CCR8: cd15187 (33 - 60)

7tmA_CCR8

7tmA_CCR8: cd15187 (67 - 92)

7tmA_CCR8

7tmA_CCR8: cd15187 (103 - 133)

7tmA_CCR8

7tmA_CCR8: cd15187 (145 - 167)

7tmA_CCR8

7tmA_CCR8: cd15187 (192 - 221)

7tmA_CCR8

7tmA_CCR8: cd15187 (228 - 258)

7tmA_CCR8

7tmA_CCR8: cd15187 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 8

  • C-C motif chemokine receptor 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-P991061 Tagmokitug Inhibitor 99.9% Phase 1
阻害性抗体 (5)
製品番号 製品名 製品効果
純度 Phase
HY-P990914 Denikitug 99.00% Phase 2
HY-P991481 S-531011 Inhibitor 98.38% Phase 2
HY-P991942 Lanerkitug Inhibitor 97.00% Phase 1
HY-P991944 ZL-1218 Inhibitor / Phase 1
HY-P991135 Enzelkitug Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-119217 AZ084 Antagonist 99.70% Unkown
HY-122219 R243 Antagonist 98.09% Unkown
HY-124416 ML604086 Inhibitor 99.78% Unkown
HY-121885 LMD-009 Agonist 99.35% Unkown
HY-101038A ZK756326 dihydrochloride Agonist 99.87% Unkown
HY-144197 CCR8 antagonist 1 Antagonist 99.50% Unkown
HY-P991942A Lanerkitug (FUT8-KO) Inhibitor 99.50% Unkown
HY-176800 LMD-902 Agonist / Unkown
HY-176799 LMD-584 Agonist / Unkown
HY-153669 SB-649701 Antagonist / Unkown
HY-184668 CCR8 agonist 2 Agonist / Unkown
HY-160647 CCR8 antagonist 3 Antagonist / Unkown
阻害性抗体 (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P991481A S-531011 (FUT8-KO) Inhibitor 99.50% Unkown
HY-P991944A ZL-1218 (FUT8-KO) Inhibitor / Unkown
HY-P992334 CM369 Inhibitor / Unkown
HY-P992365 HFB101110 Inhibitor / Unkown
HY-P991135A Enzelkitug (FUT8-KO) Inhibitor / Unkown
HY-P991782 Anti-Mouse CCR8 Antibody (C8Mab-2) Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Ccr8 NCBI NCBI:1237