Kng1 - kininogen 1 Gene

Predicted to enable cysteine-type endopeptidase inhibitor activity; Protease binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including blood coagulation; negative regulation of peptidase activity; and vasodilation. Located in collagen-containing extracellular matrix. Is expressed in yolk sac. Human ortholog(s) of this gene implicated in high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Apr 2022]