Serpine2 - serine (or cysteine) peptidase inhibitor, clade E, member 2 Gene

Also Known as PI7; PI-7; PN-1; Spi4; PAI-1; B230326M24Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 20720

Summary

Enables serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in negative regulation of plasminogen activation and negative regulation of platelet aggregation. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Located in extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; limb; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (Serpin family E member 2). [provided by Alliance of Genome Resources, Apr 2022]

Serpine2 Products (1)

mRNA Protein Name
NM_009255.4 NP_033281.1 glia-derived nexin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables serine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
11248026 MGI
enables signaling receptor binding IGI
IGI: Inferred from genetic interaction
17409116 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
19855083 MGI
acts upstream of or within cerebellar granular layer morphogenesis IMP
IMP: Inferred from mutant phenotype
17409116 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
15509762 MGI
acts upstream of or within innervation IMP
IMP: Inferred from mutant phenotype
17409231 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
9169529 MGI
acts upstream of or within mating plug formation IMP
IMP: Inferred from mutant phenotype
11248026 MGI
acts upstream of or within negative regulation of cell growth IGI
IGI: Inferred from genetic interaction
18398001 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18398001 MGI
acts upstream of or within negative regulation of peptidase activity IMP
IMP: Inferred from mutant phenotype
15509762 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
18398001 MGI
involved in negative regulation of plasminogen activation IMP
IMP: Inferred from mutant phenotype
19855083 MGI
acts upstream of or within negative regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
19855083 MGI
involved in negative regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
19855083 MGI
involved in negative regulation of platelet aggregation IMP
IMP: Inferred from mutant phenotype
19855083 MGI
acts upstream of or within negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
15509762 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
17409116 MGI
acts upstream of or within negative regulation of sodium ion transport IGI
IGI: Inferred from genetic interaction
16941024 MGI
acts upstream of or within negative regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
16941024 MGI
acts upstream of platelet activation IMP
IMP: Inferred from mutant phenotype
19855083 MGI
acts upstream of protein catabolic process IMP
IMP: Inferred from mutant phenotype
15509762 MGI
acts upstream of or within regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
15509762 MGI
acts upstream of or within regulation of timing of cell differentiation IMP
IMP: Inferred from mutant phenotype
17409116 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
17409231 MGI
acts upstream of or within secretion by cell IMP
IMP: Inferred from mutant phenotype
16319172 MGI
acts upstream of or within secretory granule organization IMP
IMP: Inferred from mutant phenotype
16319172 MGI
acts upstream of or within seminal vesicle epithelium development IMP
IMP: Inferred from mutant phenotype
11248026 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in extracellular region IDA
IDA: Inferred from direct assay
2037625 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
2037625 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glia-derived nexin

  • GDN

  • peptidase inhibitor 7

  • protease nexin 1

  • protease nexin I

  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

  • serine (or cysteine) proteinase inhibitor, clade E, member 2

  • serine protease-inh

Recombinant Serpine2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71294 Serpin E2 Protein, Mouse (HEK293, His) Q07235 (S20-P397) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12723 SERPINE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17933 Serpine2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24403 Serpine2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Serpine2 NCBI NCBI:5270