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CDK20 - cyclin dependent kinase 20 Gene

Also Known as P42; CCRK; CDCH; PNQALRE

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23552

About CDK20

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:87,966,441-87,974,533 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 26 paralogues. Broad expression in testis (RPKM 10.2), adrenal (RPKM 7.6) and 24 other tissues.

Summary

The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein Kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]

CDK20 Products (5)

mRNA	Protein	Name
NM_001039803.3	NP_001034892.1	cyclin-dependent kinase 20 isoform 3
NM_001170639.2	NP_001164110.1	cyclin-dependent kinase 20 isoform 4
NM_001170640.2	NP_001164111.1	cyclin-dependent kinase 20 isoform 5
NM_012119.5	NP_036251.2	cyclin-dependent kinase 20 isoform 2
NM_178432.4	NP_848519.1	cyclin-dependent kinase 20 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	21986944	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK20 Protein Structure

Pkinase

0
100
200
300
346 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 20	CAK-kinase p42

CDK20 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CDK20	Q8IZL9	TRIM2	Homo sapiens	Q9C040	Y2H Prey Pooling	26871637
Intra	CDK20	Q8IZL9	TRIM2	Homo sapiens	Q9C040	Validated Y2H	26871637
Intra	CDK20	Q8IZL9	TRIM2	Homo sapiens	Q9C040	Y2H Array	26871637

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Endocrine-Cerebroosteodysplasia	Endocrine-Cerebro-Osteodysplasia Syndrome ECO Eco Syndrome
Nephrotic Syndrome, Type 22	NPHS22 Nephrotic Syndrome Type 22 Nephrotic Syndrome 22
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS28035	Cdk20 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	CDK20	VGNC	VGNC:27124
Macaca mulatta	CDK20	VGNC	VGNC:71070
Felis catus	CDK20	VGNC	VGNC:60698
Rattus norvegicus	CDK20	RGD	RGD:1305219
Canis familiaris	CDK20	VGNC	VGNC:39052
Mus musculus	CDK20	MGD	MGI:2145349
Others	CDK20	NCBI