DCAF4 - DDB1 and CUL4 associated factor 4 Gene

Also Known as WDR21; WDR21A

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 26094

About DCAF4

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:72,926,464-72,962,098 (from NCBI)

This gene has 15 transcripts (splice variants), 89 orthologues and 26 paralogues. Ubiquitous expression in thyroid (RPKM 4.7), testis (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 Ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

DCAF4 Products (8)

mRNA	Protein	Name
NM_001163508.2	NP_001156980.1	DDB1- and CUL4-associated factor 4 isoform 4
NM_001163509.2	NP_001156981.1	DDB1- and CUL4-associated factor 4 isoform 5
NM_001352447.2	NP_001339376.1	DDB1- and CUL4-associated factor 4 isoform 6
NM_001352448.3	NP_001339377.1	DDB1- and CUL4-associated factor 4 isoform 7
NM_001352449.2	NP_001339378.1	DDB1- and CUL4-associated factor 4 isoform 8
NM_015604.4	NP_056419.2	DDB1- and CUL4-associated factor 4 isoform 1
NM_181340.3	NP_851937.1	DDB1- and CUL4-associated factor 4 isoform 2
NM_181341.3	NP_851938.2	DDB1- and CUL4-associated factor 4 isoform 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	19966799	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF4 Protein Structure

WD40

0
100
200
300
400
495 a.a.

Protein Preferred Names	Protein Names
DDB1- and CUL4-associated factor 4	WD repeat domain 21A

DCAF4 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DCAF4	Q8WV16	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	30945288
Intra	DCAF4	Q8WV16	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	33961781
Intra	DCAF4	Q8WV16	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	28514442
Intra	DCAF4	Q8WV16	ST7	Homo sapiens	Q9NRC1	Anti Tag CoIP	30945288

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Microphthalmia, Isolated 2	Isolated Microphthalmia 2 MCOP2 Anophthalmia, Clinical, Isolated Microphthalmia, Isolated, 2 Isolated Clinical Anophthalmia Microphthalmia, Isolated, Type 2
Atrial Septal Defect 9	ASD9 Atrial Heart Septal Defect 9 Septal Defect, Atrial, Type 9
Xeroderma Pigmentosum Group E	Xeroderma Pigmentosum, Group E Xeroderma Pigmentosum V Xp Group E Xp5 Xpe Xeroderma Pigmentosum, Complementation Group E
Isolated Microphthalmia
Retroperitoneal Leiomyosarcoma
Atrial Septal Defect 5	ASD5 Atrial Heart Septal Defect 5 Septal Defect, Atrial, Type 5
Atrial Septal Defect 1	ASD1 Atrial Heart Septal Defect 1 Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03564	DCAF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03565	DCAF4L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22465	Dcaf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28988	Dcaf4 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	DCAF4	RGD	RGD:1306241
Canis familiaris	DCAF4	VGNC	VGNC:50445
Mus musculus	DCAF4	MGD	MGI:1921078
Macaca mulatta	DCAF4	VGNC	VGNC:84331
Others	DCAF4	NCBI