DCAF4 - DDB1 and CUL4 associated factor 4 Gene

Also Known as WDR21; WDR21A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26094

About DCAF4

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:72,926,464-72,962,098 (from NCBI)

This gene has 15 transcripts (splice variants), 89 orthologues and 26 paralogues. Ubiquitous expression in thyroid (RPKM 4.7), testis (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 Ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

DCAF4 Products (8)

mRNA Protein Name
NM_001163508.2 NP_001156980.1 DDB1- and CUL4-associated factor 4 isoform 4
NM_001163509.2 NP_001156981.1 DDB1- and CUL4-associated factor 4 isoform 5
NM_001352447.2 NP_001339376.1 DDB1- and CUL4-associated factor 4 isoform 6
NM_001352448.3 NP_001339377.1 DDB1- and CUL4-associated factor 4 isoform 7
NM_001352449.2 NP_001339378.1 DDB1- and CUL4-associated factor 4 isoform 8
NM_015604.4 NP_056419.2 DDB1- and CUL4-associated factor 4 isoform 1
NM_181340.3 NP_851937.1 DDB1- and CUL4-associated factor 4 isoform 2
NM_181341.3 NP_851938.2 DDB1- and CUL4-associated factor 4 isoform 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19966799 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16949367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF4 Protein Structure

WD40

WD40: WD domain, G-beta repeat (368 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

DDB1- and CUL4-associated factor 4

  • WD repeat domain 21A

DCAF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DCAF4 Q8WV16 DDB1 Homo sapiens Q16531
Anti Tag CoIP
30945288
Intra
DCAF4 Q8WV16 DDB1 Homo sapiens Q16531
Anti Tag CoIP
33961781
Intra
DCAF4 Q8WV16 DDB1 Homo sapiens Q16531
Anti Tag CoIP
28514442
Intra
DCAF4 Q8WV16 ST7 Homo sapiens Q9NRC1
Anti Tag CoIP
30945288
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microphthalmia, Isolated 2

  • Isolated Microphthalmia 2

  • MCOP2

  • Anophthalmia, Clinical, Isolated

  • Microphthalmia, Isolated, 2

  • Isolated Clinical Anophthalmia

  • Microphthalmia, Isolated, Type 2
Atrial Septal Defect 9

  • ASD9

  • Atrial Heart Septal Defect 9

  • Septal Defect, Atrial, Type 9
Xeroderma Pigmentosum Group E

  • Xeroderma Pigmentosum, Group E

  • Xeroderma Pigmentosum V

  • Xp Group E

  • Xp5

  • Xpe

  • Xeroderma Pigmentosum, Complementation Group E
Isolated Microphthalmia
Retroperitoneal Leiomyosarcoma
Atrial Septal Defect 5

  • ASD5

  • Atrial Heart Septal Defect 5

  • Septal Defect, Atrial, Type 5
Atrial Septal Defect 1

  • ASD1

  • Atrial Heart Septal Defect 1

  • Asd
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03564 DCAF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03565 DCAF4L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22465 Dcaf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DCAF4 RGD RGD:1306241
Canis familiaris DCAF4 VGNC VGNC:50445
Mus musculus DCAF4 MGD MGI:1921078
Macaca mulatta DCAF4 VGNC VGNC:84331
Others DCAF4 NCBI