FETUB - fetuin B Gene

Also Known as 16G2; Gugu; IRL685

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 26998

About FETUB

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,635,969-186,653,141 (from NCBI)

This gene has 8 transcripts (splice variants), 268 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 42.7).

Summary

The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine Protease Inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the Insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

FETUB Products (9)

mRNA Protein Name
NM_001308077.4 NP_001295006.1 fetuin-B isoform 2 precursor
NM_001308079.4 NP_001295008.1 fetuin-B isoform 3 precursor
NM_001375587.2 NP_001362516.1 fetuin-B isoform 1 precursor
NM_001375588.2 NP_001362517.1 fetuin-B isoform 5
NM_001375589.2 NP_001362518.1 fetuin-B isoform 6
NM_001375590.2 NP_001362519.1 fetuin-B isoform 6
NM_001375591.2 NP_001362520.1 fetuin-B isoform 6
NM_001375592.2 NP_001362521.1 fetuin-B isoform 6
NM_014375.3 NP_055190.2 fetuin-B isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FETUB Protein Structure

Cystatin

Cystatin: Cystatin domain (37 - 120)

Cystatin

Cystatin: Cystatin domain (158 - 246)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

fetuin-B

  • fetuin-like protein IRL685

FETUB Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
FETUB Q9UGM5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
FETUB Q9UGM5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
FETUB Q9UGM5 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
FETUB Q9UGM5 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
FETUB Q9UGM5 DARS2 Homo sapiens Q6PI48
Y2H Prey Pooling
32296183
Intra
FETUB Q9UGM5 DARS2 Homo sapiens Q6PI48
Y2H Array
32296183
Intra
FETUB Q9UGM5 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
FETUB Q9UGM5 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
FETUB Q9UGM5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
FETUB Q9UGM5 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
FETUB Q9UGM5 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
FETUB Q9UGM5 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
FETUB Q9UGM5 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FETUB Proteins

製品番号 製品名 アクセッション番号 純度
HY-P70930 Fetuin B Protein, Human (HEK293, His) Q9UGM5-1 (C16-P382) ≥ 95%, as determined by reducing SDS-PAGE.

FETUB 抗体

製品番号 製品名 アプリケーション 反応性
HY-P86882 Fetuin B Antibody (YA6575) WB, IHC-P Human, Mouse, Rat

関連疾患

Diseases Alias
Encephalitozoonosis

  • Infection By Encephalitozoon
Caffey Disease

  • Infantile Cortical Hyperostosis

  • CAFYD

  • Cortical Congenital Hyperostosis

  • Caffey-Silverman Syndrome

  • De Toni-Caffey Disease

  • Hyperostosis Cortical Infantile

  • Hyperostosis, Cortical, Congenital
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04868 FETUB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19001 Fetub Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25490 Fetub Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris FETUB VGNC VGNC:40826
Rattus norvegicus FETUB RGD RGD:69293
Felis catus FETUB VGNC VGNC:62233
Mus musculus FETUB MGD MGI:1890221
Bos taurus FETUB VGNC VGNC:28955
Macaca mulatta FETUB VGNC VGNC:72638
Others FETUB NCBI