CERS2 - ceramide synthase 2 Gene

Also Known as L3; LASS2; SP260; TMSG1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 29956

About CERS2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,965,186-150,974,835 (from NCBI)

This gene has 14 transcripts (splice variants), 275 orthologues and 5 paralogues. Ubiquitous expression in liver (RPKM 113.9), adrenal (RPKM 85.4) and 25 other tissues.

Summary

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

CERS2 Products (2)

mRNA Protein Name
NM_022075.5 NP_071358.1 ceramide synthase 2
NM_181746.4 NP_859530.1 ceramide synthase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
11543633 GOA
enables sphingosine N-acyltransferase activity IDA
IDA: Inferred from direct assay
17977534 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
17977534 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18165233 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CERS2 Protein Structure

Homeobox

Homeobox: Homeobox domain (82 - 126)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (132 - 325)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

ceramide synthase 2

  • LAG1 homolog, ceramide synthase 2

CERS2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CERS2 Q96G23 ASGR1 Homo sapiens P07306
Y2H
11543633
Intra
CERS2 Q96G23 ASGR1 Homo sapiens P07306
Pull Down
11543633
Intra
CERS2 Q96G23 ASGR2 Homo sapiens P07307
Y2H
21988832
Intra
CERS2 Q96G23 ASGR2 Homo sapiens P07307
Y2H
11543633
Intra
CERS2 Q96G23 ASGR2 Homo sapiens P07307
Pull Down
11543633
Intra
CERS2 Q96G23 SLC22A1 Homo sapiens O15245
Y2H
11543633
Intra
CERS2 Q96G23 ATP6V0C Homo sapiens P27449
Pull Down
11543633
Intra
CERS2 Q96G23 ATP6V0C Homo sapiens P27449
Y2H
21988832
Intra
CERS2 Q96G23 ATP6V0C Homo sapiens P27449
Y2H
11543633
Intra
CERS2 Q96G23 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Myoclonic Epilepsy, Juvenile 3

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 3

  • EJM3

  • Epilepsy, Juvenile Myoclonic 3

  • Juvenile Myoclonic Epilepsy 3
Hereditary Sensory And Autonomic Neuropathy Type 1

  • Hereditary Sensory And Autonomic Neuropathy Type I

  • Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

  • Hsan1e

  • Hsan1

  • Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

  • Hsn1e

  • Hsnie

  • Hereditary Sensory Neuropathy Type Ie

  • Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

  • Hereditary Sensory And Autonomic Neuropathy Type Ie

  • Hereditary Sensory And Autonomic Neuropathy Type 1e

  • Hereditary Sensory Neuropathy With Hearing Loss And Dementia

  • Dnmt1-Complex Disorder

  • Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

  • Hsn Ie

  • Hereditary Sensory Autonomic Neuropathy, Type 1

  • Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-133490A ST1074 Inducer 99.41% Unkown
HY-133491 ST1060 Inhibitor 96.90% Unkown
HY-183140 DH20931 Activator / Unkown
HY-RS02537 CERS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22435 Cers2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28958 Cers2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta CERS2 VGNC VGNC:70946
Felis catus CERS2 VGNC VGNC:60792
Mus musculus CERS2 MGD MGI:1924143
Bos taurus CERS2 VGNC VGNC:27224
Rattus norvegicus CERS2 RGD RGD:1310059
Canis familiaris CERS2 VGNC VGNC:39148
Others CERS2 NCBI