THEMIS - thymocyte selection associated Gene

Also Known as GASP; SPOT; TSEPA; C6orf190; C6orf207

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 387357

About THEMIS

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,696,628-127,918,595 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 167 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 2.2), appendix (RPKM 1.1) and 12 other tissues.

Summary

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

THEMIS Products (7)

mRNA Protein Name
NM_001010923.3 NP_001010923.1 protein THEMIS isoform 2
NM_001164685.2 NP_001158157.1 protein THEMIS isoform 1
NM_001164687.2 NP_001158159.1 protein THEMIS isoform 3
NM_001318531.1 NP_001305460.1 protein THEMIS isoform 4
NM_001394520.1 NP_001381449.1 protein THEMIS isoform 5
NM_001394521.1 NP_001381450.1 protein THEMIS isoform 6
NM_001394522.1 NP_001381451.1 protein THEMIS isoform 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
21189249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THEMIS Protein Structure

CABIT

CABIT: Cell-cycle sustaining, positive selection, (17 - 270)

CABIT

CABIT: Cell-cycle sustaining, positive selection, (281 - 533)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 641 a.a.
Protein Preferred Names Protein Names

protein THEMIS

  • GRB2-associated protein

THEMIS Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Anti Tag CoIP
28046066
Intra
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Anti Bait CoIP
21189249
Intra
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Anti Tag CoIP
33961781
Intra
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Pull Down
21189249
Intra
THEMIS Q8N1K5 GRB2 Homo sapiens P62993
Pull Down
25535246
Intra
THEMIS Q8N1K5 PTPN6 Homo sapiens P29350
Pull Down
25535246
Intra
THEMIS Q8N1K5 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
Intra
THEMIS Q8N1K5 PRMT6 Homo sapiens Q96LA8
Anti Tag CoIP
23455924
Cross
THEMIS Q8N1K5 HBZ Human T-cell leukemia virus 1 P0C745
Anti Tag CoIP
28046066
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Developmental Coordination Disorder

  • Motor Skills Disorders
Lynch Syndrome I

  • Lynch Syndrome 1

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 1

  • HNPCC1

  • Fcc1

  • Lynch Syndrome Ii

  • Colon Cancer, Familial Nonpolyposis, Type 1

  • Coca1

  • Familial Nonpolyposis Colon Cancer Type 1

  • Hereditary Nonpolyposis Colorectal Cancer Type 1

  • Hereditary Non-Polyposis Colorectal Cancer 1

  • Hereditary Non-Polyposis Colorectal Cancer 3

  • Hnpcc3

  • Lynch Cancer Family Syndrome

  • Lynch Syndrome

  • Lynch Syndrome Type I

  • Lynch Syndrome Type Ii

  • Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1

  • Hereditary Nonpolyposis Colorectal Cancer

  • Colorectal Cancer, Hereditary Nonpolyposis, Type 3

  • Hereditary Non-Polyposis Colon Cancer Type 2
Diamond-Blackfan Anemia 1

  • Aase Syndrome

  • DBA1

  • Erythrogenesis Imperfecta

  • Aase-Smith Syndrome Ii

  • Dba

  • Blackfan-Diamond Syndrome

  • Bds

  • Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

  • Anemia, Congenital Erythroid Hypoplastic

  • Red Cell Aplasia, Pure, Hereditary

  • Aregenerative Anemia, Chronic Congenital

  • Rps19-Related Diamond-Blackfan Anemia

  • Chronic Congenital Aregenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Diamond-Blackfan, Type 1

  • Anemia, Diamond-Blackfan

  • Aase Smith Syndrome 2

  • Familial Hypoplastic Anaemia With Malformations

  • Constitutional Pure Red Cell Aplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14488 THEMIS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14489 THEMIS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus THEMIS MGD MGI:2443552
Felis catus THEMIS VGNC VGNC:66161
Macaca mulatta THEMIS VGNC VGNC:83496
Bos taurus THEMIS VGNC VGNC:35835
Rattus norvegicus THEMIS RGD RGD:1560849
Canis familiaris THEMIS VGNC VGNC:47343
Others THEMIS NCBI