LANCL2 - LanC like glutathione S-transferase 2 Gene

Also Known as TASP; GPR69B

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 55915

About LANCL2

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:55,365,337-55,433,737 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 16.9), testis (RPKM 9.1) and 24 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LANCL2 Products (1)

mRNA	Protein	Name
NM_018697.4	NP_061167.1	lanC-like protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	16979580	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	16979580	GOA
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	16979580	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12566319	GOA
involved in positive regulation of abscisic acid-activated signaling pathway	IDA IDA: Inferred from direct assay	19667068	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	16979580	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12566319	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12566319	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12566319	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LANCL2 Protein Structure

LANC_like

0
100
200
300
400
450 a.a.

Protein Preferred Names	Protein Names
lanC-like protein 2	G protein-coupled receptor 69B

LANCL2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	LANCL2	Q9NS86	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Prey Pooling	32296183
Intra	LANCL2	Q9NS86	SIAH1	Homo sapiens	Q8IUQ4-2	Y2H Array	32296183
Intra	LANCL2	Q9NS86	TDRKH	Homo sapiens	Q9Y2W6	Y2H Prey Pooling	32296183
Intra	LANCL2	Q9NS86	TDRKH	Homo sapiens	Q9Y2W6	Validated Y2H	32296183
Intra	LANCL2	Q9NS86	TDRKH	Homo sapiens	Q9Y2W6	Y2H Array	32296183
Intra	LANCL2	Q9NS86	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	LANCL2	Q9NS86	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	LANCL2	Q9NS86	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	LANCL2	Q9NS86	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	LANCL2	Q9NS86	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Phase
HY-100560	Abscisic acid	Ligand	99.78%	Phase 4
HY-102013	Omilancor	Activator	98.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-100560S	Abscisic acid-d6	Ligand	99.14%	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	LANCL2	VGNC	VGNC:49916
Felis catus	LANCL2	VGNC	VGNC:68017
Mus musculus	LANCL2	MGD	MGI:1919085
Rattus norvegicus	LANCL2	RGD	RGD:1310809
Bos taurus	LANCL2	VGNC	VGNC:30784
Macaca mulatta	LANCL2	VGNC	VGNC:81630
Others	LANCL2	NCBI