PXMP2 - peroxisomal membrane protein 2 Gene

Also Known as PMP22; MPV17L3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 5827

About PXMP2

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,687,587-132,704,985 (from NCBI)

This gene has 5 transcripts (splice variants), 172 orthologues and 3 paralogues. Broad expression in liver (RPKM 47.9), kidney (RPKM 25.6) and 25 other tissues.

Summary

Located in peroxisomal membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

PXMP2 Products (1)

mRNA	Protein	Name
NM_018663.3	NP_061133.1	peroxisomal membrane protein 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	11590176	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	8624723	GOA
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	11590176	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	18174172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PXMP2 Protein Structure

Mpv17_PMP22

0
100
195 a.a.

Protein Preferred Names	Protein Names
peroxisomal membrane protein 2	22 kDa peroxisomal membrane protein

PXMP2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	PXMP2	Q9NR77	SIVA1	Homo sapiens	O15304	Y2H	16683188
Intra	PXMP2	Q9NR77	SIVA1	Homo sapiens	O15304	Pull Down	16683188
Intra	PXMP2	Q9NR77	PEX19	Homo sapiens	P40855	Anti Tag CoIP	14709540

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS11482	PXMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22756	Pxmp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	PXMP2	RGD	RGD:61812
Mus musculus	PXMP2	MGD	MGI:107487
Macaca mulatta	PXMP2	VGNC	VGNC:76628
Bos taurus	PXMP2	VGNC	VGNC:33584
Felis catus	PXMP2	VGNC	VGNC:80470
Canis familiaris	PXMP2	VGNC	VGNC:45220
Others	PXMP2	NCBI