RLN1 - relaxin 1 Gene

Also Known as H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 6013

About RLN1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,334,930-5,340,916 (from NCBI)

This gene has 2 transcripts (splice variants), 81 orthologues and 3 paralogues. Biased expression in prostate (RPKM 8.0) and testis (RPKM 0.2).

Summary

Relaxins are known endocrine and autocrine/paracrine Hormones, belonging to the Insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]

RLN1 Products (1)

mRNA	Protein	Name
NM_006911.4	NP_008842.1	prorelaxin H1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RLN1 Protein Structure

Insulin

0
100
185 a.a.

Protein Preferred Names	Protein Names
prorelaxin H1	preprorelaxin H1

RLN1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	RLN1	P04808	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	RLN1	P04808	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	RLN1	P04808	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	RLN1	P04808	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	RLN1	P04808	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RLN1 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P77176	RLN1/Relaxin-1 Protein, Human (HEK293, His)	P04808 (V23-C185)	≥ 90%, as determined by reducing SDS-PAGE.

RLN1 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82110	Relaxin 2 Antibody (YA1855)	WB, IHC-P	Human, Mouse, Rat
HY-P82110A	Relaxin 2 Antibody (YA1855)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Diseases	Alias
Spermatogenic Failure 8	SPGF8
Extragonadal Germ Cell Cancer	Extragonadal Germ Cell Tumor Extragonadal Germ Cell Malignant Tumor Neoplasm Of Extragonadal Germ Cell Tumor Of Extragonadal Germ Cell
Chromosome 9p Deletion Syndrome	Monosomy 9p Monosomy 9p Syndrome Alfi Syndrome 9p Syndrome Chromosome 9p Deletion 9p Deletion 9p Monosomy Deletion 9p Partial Monosomy 9p 9p Deletion Syndrome 9p- Syndrome Alfi'S Syndrome Chromosome 9, Partial Trisomy 9p
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12009	RLN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21424	Rln1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27942	Rln1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	RLN1	RGD	RGD:3579
Mus musculus	RLN1	MGD	MGI:97931