KREMEN2 - kringle containing transmembrane protein 2 Gene

Also Known as KRM2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 79412

About KREMEN2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,964,275-2,968,380 (from NCBI)

This gene has 6 transcripts (splice variants), 99 orthologues and 1 paralogue. Biased expression in skin (RPKM 2.2), brain (RPKM 0.7) and 7 other tissues.

Summary

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (Wnt)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the Wnt receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

KREMEN2 Products (4)

mRNA Protein Name
NM_001253725.2 NP_001240654.1 kremen protein 2 isoform e precursor
NM_001253726.2 NP_001240655.1 kremen protein 2 isoform f precursor
NM_024507.4 NP_078783.1 kremen protein 2 isoform b precursor
NM_172229.3 NP_757384.1 kremen protein 2 isoform d precursor

KREMEN2 Protein Structure

Kringle

Kringle: Kringle domain (36 - 119)

WSC

WSC: WSC domain (124 - 205)

CUB

CUB: CUB domain (219 - 323)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

kremen protein 2

  • dickkopf receptor 2

Recombinant KREMEN2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P77976 Kremen-2 Protein, Human (HEK293, His) Q8NCW0-1 (G26-A364) ≥ 95%, as determined by Bis-Tris PAGE.

関連疾患

Diseases Alias
Sclerosteosis 2

  • SOST2

  • Sclerosteosis, Type 2
Robinow Syndrome, Autosomal Recessive 1

  • Robinow Syndrome, Autosomal Recessive

  • Autosomal Recessive Robinow Syndrome

  • Covesdem Syndrome

  • RRS1

  • Costovertebral Segmentation Defect-Mesomelia Syndrome

  • Rrs

  • Costovertebral Segmentation Defect With Mesomelia, Formerly

  • Covesdem Syndrome, Formerly

  • Costovertebral Segmentation Defect With Mesomelia

  • Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

  • Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly

  • Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

  • Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly

  • Robinow, Autosomal Recessive Syndrome, Type 1
Robinow Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07429 KREMEN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18439 Kremen2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24921 Kremen2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P992252 Anti-Kremen2 Antibody / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus KREMEN2 MGD MGI:1920266
Macaca mulatta KREMEN2 VGNC VGNC:74081
Felis catus KREMEN2 VGNC VGNC:63168
Rattus norvegicus KREMEN2 RGD RGD:1310795
Bos taurus KREMEN2 VGNC VGNC:58604
Canis familiaris KREMEN2 VGNC VGNC:42512
Others KREMEN2 NCBI