TSPAN14 - tetraspanin 14 Gene

Also Known as TM4SF14; DC-TM4F2; tspan-14

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 81619

About TSPAN14

This gene has 10 transcripts (splice variants), 199 orthologues and 32 paralogues. Ubiquitous expression in fat (RPKM 22.8), placenta (RPKM 20.4) and 25 other tissues.

Summary

Enables enzyme binding activity. Involved in positive regulation of Notch signaling pathway; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TSPAN14 Products (9)

mRNA Protein Name
NM_001128309.3 NP_001121781.1 tetraspanin-14 isoform 2
NM_001351266.2 NP_001338195.1 tetraspanin-14 isoform 1
NM_001351267.4 NP_001338196.1 tetraspanin-14 isoform 1
NM_001351268.2 NP_001338197.1 tetraspanin-14 isoform 1
NM_001351269.2 NP_001338198.1 tetraspanin-14 isoform 1
NM_001351270.2 NP_001338199.1 tetraspanin-14 isoform 1
NM_001351271.2 NP_001338200.1 tetraspanin-14 isoform 1
NM_001351272.2 NP_001338201.1 tetraspanin-14 isoform 1
NM_030927.4 NP_112189.2 tetraspanin-14 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables enzyme binding IPI
IPI: Inferred from physical interaction
23091066 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23091066 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
23091066 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23035126 GOA
involved in protein maturation IMP
IMP: Inferred from mutant phenotype
23091066 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in plasma membrane IDA
IDA: Inferred from direct assay
23091066 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN14 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (16 - 259)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

tetraspanin-14

  • tetraspanin similar to TM4SF9

TSPAN14 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TSPAN14 Q8NG11 ADAM10 Homo sapiens O14672
Anti Bait CoIP
26686862
Intra
TSPAN14 Q8NG11 ADAM10 Homo sapiens O14672
Anti Tag CoIP
26686862
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Niemann-Pick Disease, Type C2

  • NPC2

  • Niemann-Pick Disease Type C2

  • Niemann-Pick C2 Disease

  • Niemann-Pick Disease C2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15162 TSPAN14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris TSPAN14 VGNC VGNC:47914
Rattus norvegicus TSPAN14 RGD RGD:1305714
Mus musculus TSPAN14 MGD MGI:1196325
Bos taurus TSPAN14 VGNC VGNC:36429
Macaca mulatta TSPAN14 VGNC VGNC:79386
Others TSPAN14 NCBI