THAP3 - THAP domain containing 3 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 90326

About THAP3

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,624,868-6,635,595 (from NCBI)

This gene has 8 transcripts (splice variants), 148 orthologues and 7 paralogues. Ubiquitous expression in kidney (RPKM 8.5), spleen (RPKM 6.2) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]

THAP3 Products (8)

mRNA Protein Name
NM_001195752.2 NP_001182681.1 THAP domain-containing protein 3 isoform 1
NM_001195753.2 NP_001182682.1 THAP domain-containing protein 3 isoform 3
NM_001394496.1 NP_001381425.1 THAP domain-containing protein 3 isoform 4
NM_001394497.1 NP_001381426.1 THAP domain-containing protein 3 isoform 5
NM_001394498.1 NP_001381427.1 THAP domain-containing protein 3 isoform 6
NM_001394499.1 NP_001381428.1 THAP domain-containing protein 3 isoform 7
NM_001394500.1 NP_001381429.1 THAP domain-containing protein 3 isoform 8
NM_138350.4 NP_612359.2 THAP domain-containing protein 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
20200153 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20200153 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THAP3 Protein Structure

THAP

THAP: THAP domain (3 - 86)

  • 0
  • 100
  • 200
  • 239 a.a.
Protein Preferred Names Protein Names

THAP domain-containing protein 3

  • THAP domain containing, apoptosis associated protein 3

THAP3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
THAP3 Q8WTV1 UBL5 Homo sapiens Q9BZL1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Brain Malformations With Or Without Urinary Tract Defects

  • Chromosome 1p32-P31 Deletion Syndrome

  • Nfia-Related Disorder

  • Chromosome 1, Monosomy 1p32

  • BRMUTD

  • 1p31p32 Microdeletion Syndrome

  • Nfia Haploinsufficiency

  • Del(1)(P31p32)

  • Monosomy 1p31p32

  • Nfia-Related Disorders
Dystonia 3, Torsion, X-Linked

  • X-Linked Dystonia-Parkinsonism

  • DYT3

  • Xdp

  • Lubag

  • Dystonia-Parkinsonism, X-Linked

  • Torsion Dystonia-Parkinsonism, Filipino Type

  • Dyt-Taf1

  • X-Linked Dystonia-Parkinsonism Syndrome

  • X-Linked Torsion Dystonia-Parkinsonism Syndrome

  • Dystonia Musculorum Deformans

  • X-Linked Dystonia-Parkinsonism/Lubag

  • Lubag Syndrome

  • Dystonia-3

  • Torsion Dystonia-Parkinsonism Filipino Type

  • X-Linked Torsion Dystonia 3

  • Dystonia, Torsion, X-Linked, Type 3
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14474 THAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus THAP3 VGNC VGNC:66150
Rattus norvegicus THAP3 RGD RGD:1308109
Macaca mulatta THAP3 VGNC VGNC:79290
Mus musculus THAP3 MGD MGI:1917126
Bos taurus THAP3 VGNC VGNC:35822
Canis familiaris THAP3 VGNC VGNC:47328
Others THAP3 NCBI