OXSR1 - oxidative stress responsive kinase 1 Gene

Also Known as OSR1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 9943

About OXSR1

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,164,063-38,255,484 (from NCBI)

This gene has 6 transcripts (splice variants), 98 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues.

Summary

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream Kinases in response to environmental stress, and may play a role in regulating the actin Cytoskeleton. [provided by RefSeq, Jul 2008]

OXSR1 Products (1)

mRNA Protein Name
NM_005109.3 NP_005100.1 serine/threonine-protein kinase OSR1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ATP binding IDA
IDA: Inferred from direct assay
14707132 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16832045 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14707132 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16669787 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16669787 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14707132 GOA
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16669787 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in cell volume homeostasis IDA
IDA: Inferred from direct assay
36318922 GOA
involved in cellular hyperosmotic response IDA
IDA: Inferred from direct assay
36318922 GOA
involved in cellular response to chemokine IMP
IMP: Inferred from mutant phenotype
27400149 GOA
involved in chemokine (C-X-C motif) ligand 12 signaling pathway IMP
IMP: Inferred from mutant phenotype
27400149 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
14707132 GOA
involved in osmosensory signaling pathway IMP
IMP: Inferred from mutant phenotype
16669787 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
24393035 GOA
involved in peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
16669787 GOA
involved in positive regulation of T cell chemotaxis IMP
IMP: Inferred from mutant phenotype
27400149 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
22052202 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14707132 GOA
involved in renal sodium ion absorption IDA
IDA: Inferred from direct assay
18270262 GOA
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
16669787 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
is active in cytoplasm IDA
IDA: Inferred from direct assay
22989884 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OXSR1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (17 - 291)

OSR1_C

OSR1_C: Oxidative-stress-responsive kinase 1 C-terminal domain (434 - 464)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 527 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase OSR1

  • oxidative stress responsive 1

OXSR1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
OXSR1 O95747 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
25416956
Intra
OXSR1 O95747 RELL2 Homo sapiens Q8NC24
Validated Y2H
25416956
Intra
OXSR1 O95747 RELL2 Homo sapiens Q8NC24
Validated Y2H
32296183
Intra
OXSR1 O95747 CAB39 Homo sapiens Q9Y376
SPR
21423148
Intra
OXSR1 O95747 WNK1 Homo sapiens Q9H4A3
Protein Kinase Assay
16832045
Intra
OXSR1 O95747 WNK1 Homo sapiens Q9H4A3
Anti Bait CoIP
16832045
Intra
OXSR1 O95747 WNK1 Homo sapiens Q9H4A3
Y2H
16832045
Intra
OXSR1 O95747 WNK1 Homo sapiens Q9H4A3
Phage Display
35044719
Intra
OXSR1 O95747 WNK1 Homo sapiens Q9H4A3
Anti Tag CoIP
35271311
Intra
OXSR1 O95747 WNK4 Homo sapiens Q96J92
SPR
17721439
Intra
OXSR1 O95747 WNK4 Homo sapiens Q96J92
Phage Display
35044719
Intra
OXSR1 O95747 WNK2 Homo sapiens Q9Y3S1
Phage Display
35044719
Intra
OXSR1 O95747 WNK2 Homo sapiens Q9Y3S1
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OXSR1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P77119 OXSR1 Protein, Human (sf9, GST) O95747 (M1-S527) ≥ 85%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Hypomagnesemia 4, Renal

  • Renal Hypomagnesemia 4

  • HOMG4

  • Hypomagnesemia, Renal, Normocalciuric

  • Hypomagnesemia 4

  • Renal Hypomagnesemia Normocalciuric

  • Hypomagnesemia, Type 4, Renal
Arthrogryposis, Distal, Type 3

  • Gordon Syndrome

  • DA3

  • Distal Arthrogryposis Type 3

  • Arthrogryposis Multiplex Congenita, Distal, Type Iia

  • Camptodactyly, Cleft Palate, And Clubfoot

  • Camptodactyly-Cleft Palate-Clubfoot Syndrome

  • Distal Arthrogryposis Multiplex Congenita Type Iia

  • Arthrogryposis Distal Type 3

  • Distal Arthrogryposis Type Iia

  • Arthrogryposis, Distal, 3

  • Pseudohypoaldosteronism, Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS09892 OXSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19467 Oxsr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25960 Oxsr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus OXSR1 RGD RGD:1310466
Felis catus OXSR1 VGNC VGNC:97546
Macaca mulatta OXSR1 VGNC VGNC:81491
Mus musculus OXSR1 MGD MGI:1917378
Canis familiaris OXSR1 VGNC VGNC:44205
Bos taurus OXSR1 VGNC VGNC:32514
Others OXSR1 NCBI