Imaprelimab
Based on 1 Customer Validation
Imaprelimab is a humanized IgG1κ anti-CD146 antibody. Imaprelimab exerts anti-angiogenic effects on brain metastasis of lung cancer in animal models. Imaprelimab can be used in studies related to brain metastasis of non-small cell lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: ≥99.0%
- CAS 番号: 2014343-04-3
- 分子量:144.74 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
体内実験
Imaprelimab (10 mg/kg; i.p.; every two days; 3 weeks) inhibits intracranial non-small cell lung carcinoma brain metastasis growth and angiogenesis more potently than Bevacizumab (HY-P9906) in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB-c-nu (female, 4-6 weeks old)[1]
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Dosage:10 mg/kg
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Administration:i.p.; every two days; 21 days
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Result:Significantly suppressed subcutaneous tumor growth compared with vehicle control and bevacizumab.
Reduced final tumor weight and lower tumor vascular density (measured via MRI F-value).
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Animal Model:BALB-c-nu (female, 4-6 weeks old)[1]
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Dosage:10 mg/kg
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Administration:i.p.; every two days; 3 weeks
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Result:Significantly suppressed intracranial tumor growth (measured via bioluminescence photo flux) compared with vehicle control and bevacizumab.
Reduced intracranial tumor vascular density (measured by CD31-positive vessel count per field) more effectively than bevacizumab.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow Cytometry analysis of Hela cells labelling MUC18/MCAM/CD146 (red) with Imaprelimab (anti-MUC18/MCAM/CD146) (HY-P99658). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
化学情報
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CAS 番号 2014343-04-3
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性状 Liquid
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分子量 144.74 kDa
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Color Colorless to light yellow
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SMILES
[Imaprelimab]
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別名
PRX-003
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Imaprelimab 関連分類
HY-P99658 関連分類
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Keywords
- Imaprelimab
- 2014343-04-3
- PRX-003
- PRX003
- PRX 003
- Transmembrane Glycoprotein
- non-small cell lung carcinoma-derived brain metastasis
- anti-angiogenic agent
- CD146
- animal models
- lung cancer brain metastasis
- intracranial non-small cell lung carcinoma brain metastasis
- bevacizumab
- subcutaneous non-small cell lung carcinoma brain metastasis mouse model
- Inhibitor
- inhibitor
- inhibit