Isaxonine
Based on 1 Customer Validation
Isaxonine acts as a modifier of the surface pH of the bilayer. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery. Isaxonine is a neurotrophic agent.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.62%
- CAS 番号: 4214-72-6
- 分子式: C7H11N3
- 分子量:137.18
-
保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Isaxonine has a favourable effect on nerve regeneration. After 8 weeks small type grouping is seen in rats receiving solvent only and large type grouping in rats treated with intraperitoneal Isaxonine. After 10 weeks a checkerboard pattern of the fibre types is observed in the muscles of animals receiving solvent only but fibre type grouping was present in those treated with Isaxonine. Isaxonine prevents synaptic remodelling by suppression of the redundant nerve endings from additional axons, which have regenerated more slowly, in making contact with motor endplates[4].
Isaxonine phosphate induces acute hepatitis which in most cases is reversible after withdrawal of the compound[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 4214-72-6
-
性状 Liquid (Density: 1.065g/cm³)
-
分子量 137.18
-
分子式 C7H11N3
-
Color Colorless to light yellow
-
SMILES
CC(C)NC1=NC=CC=N1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 100 mg/mL (728.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (272 KB)
-
SDS (453 KB)
- English - EN (453 KB)
- Français - FR (453 KB)
- Deutsch - DE (453 KB)
- Norwegian - NO (453 KB)
- Español - ES (453 KB)
- Swedish - SV (453 KB)
- Italian - IT (453 KB)
- Korean - KR (453 KB)
- Portuguese - PT (453 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. De Bleecker J, et al. Influence of isaxonine on the target phenomenon, muscle fibre size and neuromuscular junction in the tenotomized and denervated gastrocnemius muscle of the rat. Acta Neuropathol. 1986;69(3-4):337-340. [Content Brief]
[2]. J De Bleecker, et al. Influence of Isaxonine on the target phenomenon, muscle fibre size and neuromuscular junction in the tenotomized and denervated gastrocnemius muscle of the rat. Acta Neuropathol. 1986;69(3-4):337-40. [Content Brief]
[3]. C M Becker, et al. Nerve and muscle regeneration after axonal division in rats treated with Isaxonine phosphate (isopropylamino-2-pyrimidine phosphate). Eur Surg Res. 1986;18(6):383-9. [Content Brief]
[4]. J De Reuck, et al. Influence of Isaxonine on reinnervation of the rat gastrocnemius muscle. Acta Neuropathol. 1987;72(4):406-8. [Content Brief]
[5]. A Davy, et al. [Hepatotoxicity of Isaxonine phosphate: 4 cases of severe subacute hepatitis]. Gastroenterol Clin Biol. 1984 Oct;8(10):715-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2897 mL | 36.4485 mL | 72.8969 mL | 182.2423 mL |
| 5 mM | 1.4579 mL | 7.2897 mL | 14.5794 mL | 36.4485 mL | |
| 10 mM | 0.7290 mL | 3.6448 mL | 7.2897 mL | 18.2242 mL | |
| 15 mM | 0.4860 mL | 2.4299 mL | 4.8598 mL | 12.1495 mL | |
| 20 mM | 0.3645 mL | 1.8224 mL | 3.6448 mL | 9.1121 mL | |
| 25 mM | 0.2916 mL | 1.4579 mL | 2.9159 mL | 7.2897 mL | |
| 30 mM | 0.2430 mL | 1.2149 mL | 2.4299 mL | 6.0747 mL | |
| 40 mM | 0.1822 mL | 0.9112 mL | 1.8224 mL | 4.5561 mL | |
| 50 mM | 0.1458 mL | 0.7290 mL | 1.4579 mL | 3.6448 mL | |
| 60 mM | 0.1215 mL | 0.6075 mL | 1.2149 mL | 3.0374 mL | |
| 80 mM | 0.0911 mL | 0.4556 mL | 0.9112 mL | 2.2780 mL | |
| 100 mM | 0.0729 mL | 0.3645 mL | 0.7290 mL | 1.8224 mL |
Isaxonine 関連分類
HY-W129456 関連分類
Powered by Bioz