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製品番号: HY-163280

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JGB-1-155

JGB-1-155 is a nicotinamide phosphoribosyltransferase (NAMPT) activator and also a reactive oxygen species (ROS) inhibitor. JGB-1-155 binds to NAMPT, thereby enhancing its catalytic activity and increasing intracellular NAD⁺ levels. JGB-1-155 alleviates the elevation of ROS levels induced by various types of damage. JGB-1-155 can be used in research related to neurodegenerative diseases.

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CAS 番号: 3011930-28-9
分子式: C₂₆H₃₈N₂O₃
分子量:426.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

JGB-1-155 構造式

CAS 番号: 3011930-28-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

EC₅₀: NAMPT (3.29 μM)

体外実験

JGB-1-155 exerts positive allosteric regulation on purified NAMPT, with an EC₅₀ of 3.29 μM and a maximum activation fold of 1.41^[1].
JGB-1-155 (3-40 μM) increases NAD⁺ levels in human THP-1 monocytes in a concentration-dependent manner by directly activating NAMPT^[1].
JGB-1-155 activates purified NAMPT enzyme with an EC₅₀ of 3.88 μM^[2].
JGB-1-155 (20-40 μM) attenuates TNFα-induced mitochondrial ROS production in mouse HT-22 hippocampal neuron cells in a concentration-dependent manner^[1].
JGB-1-155 (1.25-40 μM) attenuates glutamate-induced mitochondrial ROS in mouse HT-22 hippocampal neuron cells in a concentration-dependent manner^[1].
JGB-1-155 (1.25-20 μM; overnight pre-incubation; overnight insult incubation) reduces ROS levels in HT-22 cells exposed to VK₃, glutamate, TNFα or hyperconfluent conditions in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3011930-28-9
分子量 426.59
分子式 C₂₆H₃₈N₂O₃
SMILES

O=C(N(CCC1(C(C)C)CCOC(C)(C1)C)CC2=CC=C(N(C)C)C=C2)C3=CC=CO3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gordon-Blake J, et al. Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS medicinal chemistry letters. 2024 Feb 08;15(2):205-214. [Content Brief]

[2]. Gordon-Blake J. Development of NAMPT Positive Allosteric Modulators as Potential Alzheimer’s Disease Therapeutics. Chicago: University of Illinois Chicago, 2022.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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