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United States

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製品番号: HY-149467

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JMX0254

JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC₅₀ for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2375960-04-4
分子式: C₂₅H₂₅Cl₂N₅O₂
分子量:498.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

JMX0254 構造式

CAS 番号: 2375960-04-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>10 μM Compound: 15; JMX0254	Cytotoxicity in human HuH7 replicon cells infected with Dengue virus 2 NGC assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-Glo reagent based assay Cytotoxicity in human HuH7 replicon cells infected with Dengue virus 2 NGC assessed as reduction in cell viability incubated for 48 hrs by Cell-titer-Glo reagent based assay	[PMID: 31403780]

化学情報

CAS 番号 2375960-04-4
分子量 498.40
分子式 C₂₅H₂₅Cl₂N₅O₂
SMILES

O=C1[C@@]2(C3=C(NC(C2)=O)N(N=N3)[C@H](C4=CC=C(C=C4)Cl)C)C5=CC(Cl)=CC=C5N1CCC(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xu J, et al. Design, synthesis, and biological evaluation of substituted 4, 6-dihydrospiro [[1, 2, 3] triazolo [4, 5-b] pyridine-7, 3′-indoline]-2′, 5 (3 H)-dione analogues as potent NS4B inhibitors for the treatment of dengue virus infection[J]. Journal of medicinal chemistry, 2019, 62(17): 7941-7960.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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