Kv3 activator-1
Based on 1 Customer Validation
Kv3 activator-1 is a Kv3 family voltage-gated potassium channel activator. Kv3 activator-1 reverses mechanical hyperalgesia in rat models of neuropathic and inflammatory pain, with rapid onset and long-lasting, dose-related effects. Kv3 activator-1 can be used for the research of pain.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.41%
- CAS 番号: 1380696-64-9
- 分子式: C20H20N4O4
- 分子量:380.40
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Kv3 activator-1 (Compound X) increased whole-cell currents of Kv3.1 and Kv3.2 potassium channels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
Kv3 activator-1 (10-60 mg/kg; i.p.; single dose) produces a dose-dependent reversal of mechanical hyperalgesia in a rat model of inflammatory pain, with peak efficacy of 92% reversal at the 60 mg/kg dose[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar Hanover (male, 225g, partial sciatic nerve ligation)[1]
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Dosage:10 mg/kg; 30 mg/kg; 60 mg/kg
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Administration:i.p.; single dose
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Result:Produced a dose-related reversal of mechanical sensitivity.
Reached peak reversal of 31% at 10 mg/kg, 73% at 30 mg/kg, and 81% at 60 mg/kg at 3 hours post-dose.
Increased contralateral paw withdrawal thresholds to mechanical pressure significantly.
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Animal Model:Wistar Hanover (male, 225g, intraplantar Freund's Complete Adjuvant (HY-153808) injection)[1]
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Dosage:10 mg/kg; 30 mg/kg; 60 mg/kg
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Administration:i.p.; single dose
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Result:Produced a dose-related reversal of mechanical sensitivity with rapid onset.
Reached peak reversal of 64% at 10 mg/kg at 3 hours post-dose, 74% at 30 mg/kg and 92% at 60 mg/kg at 1 hour post-dose.
Maintained significant reversal of 45% at 6 hours post-dose with 60 mg/kg.
化学情報
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CAS 番号 1380696-64-9
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性状 Solid
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分子量 380.40
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分子式 C20H20N4O4
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Color White to light yellow
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SMILES
O=C1N(C2=CN=C(OC3=C4C5(CC5)COC4=C(C)C=C3)N=C2)C(C(C)(C)N1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
プロトコル
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Formalin-Induced Paw Inflammation/Nociceptive Inflammation
The formalin-induced paw inflammation/nociceptive test is a chemical persistent pain model in rodents in which subcutaneous injection of formalin into the hind paw produces spontaneous nocifensive behaviors such as flinching and licking. The response is classically biphasic, consisting of an early acute phase (Phase I) reflecting direct activation of peripheral nociceptors (particularly C-fiber afferents), followed by a later prolonged phase (Phase II) associated with central sensitization in the spinal dorsal horn driven by sustained afferent input and inflammatory signaling. This model is widely used to evaluate analgesic and anti-inflammatory interventions because it captures both peripheral nociception and central sensitization processes within a single assay system.
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Kv3 activator-1 関連分類
HY-111996 関連分類
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Keywords
- Kv3 activator-1
- 1380696-64-9
- Potassium Channel
- Kv3.3 voltage-gated potassium channels
- Kv3 family voltage-gated potassium channel
- Kv3.1 voltage-gated potassium channels
- inflammatory pain
- whole-cell currents
- anti-hyperalgesic agent
- rat models
- Kv3.2 voltage-gated potassium channels
- mechanical hyperalgesia
- neuropathic pain
- Inhibitor
- inhibitor
- inhibit