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United States

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Total: USD 0.00 Checkout

製品番号: HY-P992538

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LP-003

LP-003 is an anti-IgE antibody that binds free human IgE with a K_d of 2.08 pM. LP-003 blocks the interaction of IgE with FcεRI and CD23, thereby preventing IgE-mediated signaling. LP-003 binds FcRn at acidic pH, reducing clearance and prolonging exposure. LP-003 inhibits IgE-mediated reporter gene expression. LP-003 can be used for research on seasonal allergic rhinitis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

LP-003 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- Target
- Conjugated
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Species Reactivity

Human

体外実験

LP-003 binds human IgE with an affinity of 2.08 pM and blocks the binding of IgE to recombinant FcεRI with approximately 20-fold higher activity than Omalizumab (HY-P9950)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Target

IgE

Conjugated

Unconjugated

アプリケーション

ELISA, FACS, Functional assay

化学情報

SMILES

[LP-003]
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Guan K, et al. LP-003, a novel high-affinity anti-IgE antibody for inadequately controlled seasonal allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled phase 2 clinical trial. Clinical and translational allergy. 2025 Jun;15(6):e70074.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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