MBTP-15324
MBTP-15324 is an allosteric inhibitor of PRODH (human Kd = 1.45 μM). MBTP-15324 attenuates PRODH-mediated proline catabolism by binding to the Cavity1 pocket, inhibits the viability, colony formation, and migration of PRODH-overexpressing lung cancer cells, and reverses inflammation-, cell adhesion-, and ECM-related transcriptional programs. MBTP-15324 can be used for lung cancer research.
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- CAS 番号: 924822-67-3
- 分子式: C20H22N2O4S
- 分子量:386.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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- 純度とドキュメンテーション
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
21.36 μM
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Inhibition of cell viability in human non-small cell lung cancer A549 cells stably overexpressing PRODH assessed by CCK-8 assay.
Inhibition of cell viability in human non-small cell lung cancer A549 cells stably overexpressing PRODH assessed by CCK-8 assay.
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42635425 |
体外実験
MBTP-15324 (50 μM; 24-72 h) reduces the viability of PRODH-overexpressing A549 and LLC cells in a time-dependent manner[1].
MBTP-15324 (50 μM; 10-14 days) effectively inhibits the clonogenic ability of PRODH-overexpressing A549 and LLC cells[1].
MBTP-15324 (50 μM; 24 h) significantly inhibits 2D directional migration of A549 and LLC cells overexpressing PRODH[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and LLC PRODH-OE
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Concentration:50 μM
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Incubation Time:24, 48, 72 h
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Result:Blunted the cell viability advantage associated with PRODH overexpression over the 72-hour observation period.
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Cell Line:A549 and LLC PRODH-OE
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Concentration:50 μM
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Incubation Time:10-14 days
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Result:Effectively blocked the pro-proliferative effect of PRODH overexpression and significantly reduced the colony formation area.
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Cell Line:A549 and LLC PRODH-OE
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Concentration:50 μM
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Incubation Time:24 h
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Result:Markedly suppressed the cell migration process, with the healing rates of both cell lines dropping below 40% and 30%.
化学情報
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CAS 番号 924822-67-3
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分子量 386.46
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分子式 C20H22N2O4S
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SMILES
CC1=CC=C(C(C(C(C2=CC=CS2)N3CCNCCO)=C(O)C3=O)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MBTP-15324 関連分類
HY-189397 関連分類
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