MC70
Based on 1 Customer Validation
MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.33%
- CAS 番号: 1031367-64-2
- 分子式: C24H25NO3
- 分子量:375.46
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
EC50: 0.69 µM (P-glycoprotein)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | EC50 |
0.05 μM
Compound: 4d
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Inhibition of human P-gp mediated [3H]vinblastine transport activity in human Caco-2 cells
Inhibition of human P-gp mediated [3H]vinblastine transport activity in human Caco-2 cells
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[PMID: 18276145] |
| MDCK | EC50 |
0.69 μM
Compound: MC70
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Activity at MDR1 (unknown origin) expressed in MDCK cells assessed as interference with calcein-AM efflux incubated for 30 mins prior to calcein-Am addition measured after 30 mins by fluorometric analysis
Activity at MDR1 (unknown origin) expressed in MDCK cells assessed as interference with calcein-AM efflux incubated for 30 mins prior to calcein-Am addition measured after 30 mins by fluorometric analysis
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[PMID: 23347803] |
| MDCK | EC50 |
0.69 μM
Compound: MC70
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Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based fluorescence assay
Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based fluorescence assay
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[PMID: 30584838] |
| MDCK | EC50 |
73 μM
Compound: MC70
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Inhibition of BCRP (unknown origin) expressed in MDCK cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechst 3334 addition measured after 30 mins by fluorescence assay
Inhibition of BCRP (unknown origin) expressed in MDCK cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechst 3334 addition measured after 30 mins by fluorescence assay
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[PMID: 30584838] |
| MDCK | EC50 |
73 μM
Compound: MC70
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Activity at BCRP (unknown origin) expressed in MDCK cells assessed as interference with rhodamine-123 efflux
Activity at BCRP (unknown origin) expressed in MDCK cells assessed as interference with rhodamine-123 efflux
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[PMID: 23347803] |
| MDCK | EC50 |
9.3 μM
Compound: MC70
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Activity at MRP1 (unknown origin) expressed in MDCK cells assessed as interference calcein-AM efflux incubated for 30 mins prior to calcein-Am addition measured after 30 mins by fluorometric analysis
Activity at MRP1 (unknown origin) expressed in MDCK cells assessed as interference calcein-AM efflux incubated for 30 mins prior to calcein-Am addition measured after 30 mins by fluorometric analysis
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[PMID: 23347803] |
| MDCK | EC50 |
9.3 μM
Compound: MC70
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Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay
Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay
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[PMID: 25379609] |
| MDCK | EC50 |
9.3 μM
Compound: MC70
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Inhibition of MRP1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay
Inhibition of MRP1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay
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[PMID: 25379609] |
| MDCK | EC50 |
9.3 μM
Compound: MC70
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Inhibition of MRP1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation incubated for 30 mins by calcein-AM dye based fluorescence assay
Inhibition of MRP1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation incubated for 30 mins by calcein-AM dye based fluorescence assay
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[PMID: 30584838] |
化学情報
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CAS 番号 1031367-64-2
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性状 Solid
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分子量 375.46
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分子式 C24H25NO3
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Color White to off-white
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SMILES
OC1=CC=C(C2=CC=C(CN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 250 mg/mL (665.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Stefano Guglielmo, et al. Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Ri [Content Brief]
[2]. Amalia Azzariti, et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670(1):74-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6634 mL | 13.3170 mL | 26.6340 mL | 66.5850 mL |
| 5 mM | 0.5327 mL | 2.6634 mL | 5.3268 mL | 13.3170 mL | |
| 10 mM | 0.2663 mL | 1.3317 mL | 2.6634 mL | 6.6585 mL | |
| 15 mM | 0.1776 mL | 0.8878 mL | 1.7756 mL | 4.4390 mL | |
| 20 mM | 0.1332 mL | 0.6658 mL | 1.3317 mL | 3.3292 mL | |
| 25 mM | 0.1065 mL | 0.5327 mL | 1.0654 mL | 2.6634 mL | |
| 30 mM | 0.0888 mL | 0.4439 mL | 0.8878 mL | 2.2195 mL | |
| 40 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL | 1.6646 mL | |
| 50 mM | 0.0533 mL | 0.2663 mL | 0.5327 mL | 1.3317 mL | |
| 60 mM | 0.0444 mL | 0.2219 mL | 0.4439 mL | 1.1097 mL | |
| 80 mM | 0.0333 mL | 0.1665 mL | 0.3329 mL | 0.8323 mL | |
| 100 mM | 0.0266 mL | 0.1332 mL | 0.2663 mL | 0.6658 mL |
MC70 関連分類
HY-113805 関連分類
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