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United States

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製品番号: HY-151503

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MPM-1

MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₄H₄₄F₆N₄O₇
分子量:734.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MPM-1 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

Autophagy^[1]

体外実験

MPM-1 (0-50 μM; 4 h) has cytotoxicity against various human cancer cell lines^[1].
MPM-1 (8.5 and 17.0 μM; 1-6 h) causes perturbation of autophagy and lysosomal swelling^[1].
MPM-1 induces the release and exposure of damage-associated molecular patterns (DAMPs) related to immunogenic cell death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Jurkat, Ramos, HSC-3, MCF-7, A375, et al.
Concentration:

0-50 μM
Incubation Time:

4 h
Result:

Exhibited potent cytotoxicity against Jurkat, Ramos, HSC-3, MCF-7, A375 with IC₅₀s of 6.62 ± 1.60 μM, 7.53 ± 2.01 μM, 8.53 ± 0.57 μM, 14.06 ± 2.71 μM, 14.52 ± 0.22 μM, respectively.

Immunofluorescence^[1]

Cell Line:

HSC-3
Concentration:

8.5 and 17.0 μM
Incubation Time:

1, 2, 4 and 6 h
Result:

Significantly increased the total number of autophagy markers p62 (substrate of autophagy) and LC3B.
Caused the distribution of the lysotracker dye more diffuse and less intense, indicating that lysosomal morphology was influenced.

Western Blot Analysis^[1]

Cell Line:

Ramos and HSC-3
Concentration:

8.5 μM for Romas and 17.0 μM for HSC-3
Incubation Time:

0.5, 1, 2, 3 and 4 h
Result:

Increased the release of high mobility group box 1 (HMGB1) from cells.

Related Protocols :

化学情報

分子量 734.73
分子式 C₃₄H₄₄F₆N₄O₇
SMILES

NCCCCN1C(N(C(C(CCCC2=CC=CC=C2)(C1=O)CCCC3=CC=CC=C3)=O)CCCCN)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Susannah von Hofsten, et al. The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines. Sci Rep. 2022 Sep 16;12(1):15586. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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