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製品番号: HY-D2978

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MR2-cy5

MR2-cy5 is a clustered mannose ligand that binds CD206 and enables fluorescence detection of CD206⁺ macrophages; its fluorescence is selective for CD206⁺ macrophages and colocalizes with CD206 immunostaining in the infarcted brain region after ischemic stroke. MR2-cy5 can be used for research on ischemic stroke.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 3038636-76-6
分子式: C₄₈H₆₇N₃O₁₉S₂
分子量:1054.18

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

MR2-cy5 構造式

CAS 番号: 3038636-76-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Innate ImmunityCytokines & Chemokines

Innate Immunity

MR2-cy5 (10 mM DMSO stock diluted 1:250; incubated at room temperature for 1 h) strongly co-localizes with CD206 immunostaining in infarcted brain sections of ischemic stroke mice^[1].

Innate Immunity

Cytokines & Chemokines

MR2-cy5 (10 mM DMSO stock diluted 1/1000; incubated at 37°C for 1 h) selectively labels IL-4-induced CD206⁺ RAW 264.7-derived macrophages in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

RAW 264.7-derived macrophages polarized to CD206⁻ (IFN-γ) or CD206⁺ (IL-4) phenotypes
Concentration:

1/1000 dilution of a 10 mM DMSO stock (MR2-cy5); 100 ng/mL (IFN-γ); 100 ng/mL (IL-4)
Incubation Time:

1 h at 37°C (MR2-cy5); 24 h (polarization)
Result:

Markedly higher fluorescence signal was produced in IL-4-induced CD206⁺ macrophages than in IFN-γ-induced CD206⁻ macrophages.

Related Protocols :

Ki-67 Immunostaining Proliferation Assay

化学情報

CAS 番号 3038636-76-6
分子量 1054.18
分子式 C₄₈H₆₇N₃O₁₉S₂
SMILES

CC[N+]1=C(/C=C/C=C/C=C2N(CCCCCC(NC(COC3O[C@@H](CO)C(O)[C@@H](O)[C@H]3O)COC4O[C@H](CO)[C@@H](O)C(O)[C@@H]4O)=O)C(C=CC(S(=O)(O)=O)=C5)=C5C/2(C)C)C(C)(C)C6=C1C=CC(S(=O)([O-])=O)=C6
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (252 KB)
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- Español - ES (252 KB)
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- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang C, et al. A specific and adaptable approach to track CD206 macrophages by molecular MRI and fluorescence imaging. Theranostics. 2025;15(3):1094-1109. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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