N42FTA
N42FTA is a non-covalent, non-suicidal inhibitor of FabA from Pseudomonas aeruginosa and Escherichia coli, with IC50 values of 3.27 μM and 2.31 μM, respectively. As a natural substrate mimetic, N42FTA blocks the cross-linking between acyl carrier protein and FabA in Escherichia coli. N42FTA shows no significant antibacterial activity due to poor permeability. N42FTA can be used in studies related to Pseudomonas aeruginosa and Escherichia coli infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 892706-90-0
- 分子式: C13H11ClN4O
- 分子量:274.71
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
N42FTA inhibits Pseudomonas aeruginosa FabA in direct ultraviolet absorption assays with an IC50 of 3.27 μM; it also inhibits Escherichia coli FabA with an IC50 of 2.31 μM[1].
N42FTA competitively inhibits Pseudomonas aeruginosa FabA in coupled fluorescence assays, with an IC50 of 2 μM (pIC50 = 5.7)[1].
N42FTA binds to Pseudomonas aeruginosa FabA, with a binding constant of 4 μM measured by isothermal titration calorimetry[1].
N42FTA (250 μM; 24 h) inhibits 94% of the cross-linking between E. coli FabA and acyl carrier protein, thereby blocking the formation of the native substrate-enzyme complex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 892706-90-0
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分子量 274.71
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分子式 C13H11ClN4O
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SMILES
ClC1=CC=C(CNC2=NC(C3=CC=CO3)=NN2)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
N42FTA 関連分類
HY-186236 関連分類
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