NARS-3′
NARS-3′ is an orally active reversible xanthine oxidase (XO) inhibitor with the IC50 of 21.01 μM. NARS-3′ can competitively inhibit XO activity and reduce uric acid production. NARS-3′ can reduce renal damage in hyperuricemia mice. NARS-3′ can be used for the study of hyperuricemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2702589-46-4
- 分子式: C15H11NaO8S
- 分子量:374.30
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
NARS-3′ (0-100 μM) exhibits dose-dependent inhibition on XO activity[1].
NARS-3′ (0-40 μM) can bind to the active site of XO and compete with xanthine substrates during the catalytic process[1].
NARS-3′ could cause the conformational changes in XO[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Potassium oxonate (250 mg/kg) injected the male Kunming mice (4 weeks)[1].
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Dosage:0.3 % carboxymethyl cellulose sodium solution
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Administration:Oral gavage (i.g.); once daily for a week
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Result:Reduced serum UA levels to 56.26 μM and reduced XO activity to 9.21 U/L.
Lowered serum CRE levels to 7.85 μM and reduce pathological damage to the kidneys.
化学情報
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CAS 番号 2702589-46-4
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分子量 374.30
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分子式 C15H11NaO8S
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SMILES
O=C1CC(OC2=CC(O)=CC(O)=C12)C3=CC(S(=O)(O[Na])=O)=C(C=C3)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NARS-3′ 関連分類
HY-174318 関連分類
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