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製品番号: HY-119014

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NU-8231

NU-8231 (Compound 2) is a p53-MDM2 binding inhibitor with an IC₅₀ of 5.3-200 μM for inhibiting the p53-MDM2 interaction. NU-8231 is applicable for cancer research.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 878022-36-7
分子式: C₂₆H₂₆ClNO₅
分子量:467.95

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NU-8231 構造式

CAS 番号: 878022-36-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NU-8231 (Compound 2) is a p53-MDM2 binding inhibitor with an IC₅₀ of 5.3-200 μM for inhibiting the p53-MDM2 interaction. NU-8231 is applicable for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
SJSA-1	IC₅₀	5.3 μM Compound: 2q	Inhibitory concentration against MDM2-p53 interaction in SJSA human sarcoma cells Inhibitory concentration against MDM2-p53 interaction in SJSA human sarcoma cells	[PMID: 15713419]

化学情報

CAS 番号 878022-36-7
分子量 467.95
分子式 C₂₆H₂₆ClNO₅
SMILES

O=C1C=2C=CC=CC2C(OCC3=CC(OC)=C(O)C(OC)=C3)(C4=CC=C(Cl)C=C4)N1CCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Beretta GL, et al. Small molecules targeting p53 to improve antitumor therapy. Mini Rev Med Chem. 2008;8(9):856-868. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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