PHST001
PHST001 is a humanized anti-CD24 antibody. PHST001 binds cell-surface CD24, blocks CD24-Siglec10 interaction, and engages Fc receptors to promote macrophage-mediated tumor cell phagocytosis. PHST001 inhibits growth of breast cancer and ovarian cancer, and reduces metastatic lesions in mouse xenograft models. PHST001 can be used for the research of triple negative breast cancer, HER2+ breast cancer, metastatic tumors, and ovarian cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Species Reactivity
Human
体外実験
PHST001 binds specifically and with high affinity to human CD24 peptide, with no cross-reactivity to CD24 peptides from other tested species or a randomized control peptide[1].
PHST001 binds with high affinity to CD24 on the surface of multiple human cancer cell lines, including BT474, MFM223, SKBR3, OVCAR3, SKOV3, NCI-H292, NCI-H1563, BXPC3, PACADD-137, HT29, and DLD1 cell lines[1].
PHST001 induces macrophage-mediated phagocytosis of human breast (BT474, SKBR3, MFM223), colorectal (HT29, DLD1), ovarian (NCI-H292, NCI-H1563, OVCAR3, SKOV3), and pancreatic (BXPC3, PACADD-137) cancer cell lines[1].
PHST001 (5-100 μg/mL) does not induce release of IL6, TNFα, IL2, or IFNγ by human PBMCs[1].
PHST001 binds CD24 on SKOV3, OVCAR3, and primary mucinous, neuroendocrine, and serous ovarian carcinoma cells with a Kd of 31 nM to 117 nM, and binds >95% of EpCam+ cells from these primary subtypes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
PHST001 inhibits the formation of axillary lymph node metastases reduces the number and size of metastatic lesions in orthotopic xenograft models of human Her2+ breast cancer in NSG mice[2].
PHST001 significantly reduces the number and size of metastatic lesions in a disseminated intracardiac xenograft model of human Her2+ breast cancer in NSG mice[2].
PHST001 significantly reduces the number and size of metastatic lesions in a disseminated intracardiac syngeneic model of BT474 in nsg mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NSG immunocompromised mice[3]
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Dosage:20 mg/kg
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Administration:s.c.; 3 times per week; 18 doses
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Result:Significantly inhibited growth of OVCAR3 ovarian cancer cell lines.
Significantly improved survival in treated mice.\n
Significantly inhibited growth of SKOV3 ovarian cancer cell lines.
Significantly improved survival in treated mice.\nEnhanced chemotherapy efficacy.
Significantly inhibited tumor growth.
Enhanced survival in treated mice.
遺伝子ID
アクセッション番号
P25063-1
Target
CD24
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
アプリケーション
ELISA, FACS, Functional assay
化学情報
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PHST001 関連分類
HY-P992441 関連分類
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