Piflufolastat
Based on 1 Customer Validation
Piflufolastat (DCFPYL) can be used for the preparation of piflufolastat F 18 (DCFPyL F-18). Piflufolastat F-18 (DCFPyL F-18) is an 18F-labeled imaging agent. Piflufolastat F-18 can be used for positron emission tomography (PET) targeting prostate-specific membrane antigen (PSMA). Piflufolastat can be used for imaging of prostate cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.18%
- CAS 番号: 1423758-00-2
- 分子式: C18H23FN4O8
- 分子量:442.40
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
1.56 nM
Compound: 1; DCFPyL
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Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAALADase assay
Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAALADase assay
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[PMID: 32097010] |
体外実験
化学情報
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CAS 番号 1423758-00-2
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性状 Solid
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分子量 442.40
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分子式 C18H23FN4O8
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Color White to off-white
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SMILES
O=C(CC[C@H](NC(N[C@@H](CCCCNC(C1=CC=C(N=C1)F)=O)C(O)=O)=O)C(O)=O)O
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別名
DCFPYL
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 175 mg/mL (395.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Keam SJ, et al. Piflufolastat F 18: Diagnostic First Approval. Mol Diagn Ther. 2021;25(5):647-656. [Content Brief]
[2]. Chen Y, et al. 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid, [18F]DCFPyL, a PSMA-based PET imaging agent for prostate cancer. Clin Cancer Res. 2011;17(24):7645-7653. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2604 mL | 11.3020 mL | 22.6040 mL | 56.5099 mL |
| 5 mM | 0.4521 mL | 2.2604 mL | 4.5208 mL | 11.3020 mL | |
| 10 mM | 0.2260 mL | 1.1302 mL | 2.2604 mL | 5.6510 mL | |
| 15 mM | 0.1507 mL | 0.7535 mL | 1.5069 mL | 3.7673 mL | |
| 20 mM | 0.1130 mL | 0.5651 mL | 1.1302 mL | 2.8255 mL | |
| 25 mM | 0.0904 mL | 0.4521 mL | 0.9042 mL | 2.2604 mL | |
| 30 mM | 0.0753 mL | 0.3767 mL | 0.7535 mL | 1.8837 mL | |
| 40 mM | 0.0565 mL | 0.2825 mL | 0.5651 mL | 1.4127 mL | |
| 50 mM | 0.0452 mL | 0.2260 mL | 0.4521 mL | 1.1302 mL | |
| 60 mM | 0.0377 mL | 0.1884 mL | 0.3767 mL | 0.9418 mL | |
| 80 mM | 0.0283 mL | 0.1413 mL | 0.2825 mL | 0.7064 mL | |
| 100 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5651 mL |
Piflufolastat 関連分類
HY-117756 関連分類
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